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TranscriptomicsAIM2-responsive genes in colorectal tumor cells
Absent in Melanoma 2 (AIM2) is a member of the HIN-200 family of hematopoietic, IFN-inducible nuclear proteins associated with infection defense and tumor pathology. Recently, AIM2 was found to act as a DNA sensor in innate immunity. In addition, a high frequency of AIM2-alterations was observed in ...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-24155 | biostudies-arrayexpress
TranscriptomicsTCDD induced gene expression changes in dendritic cells
Effect of the over activation of the aryl hydrocarbon receptor on gene expression of spleen derived dendritic cells. 8-12 week old, female C57BL6 mice were injected 10 µg/kg TCDD i.p. or solvent control. After 24 h mice were sacrificed and splenic dendritic cells purified by MACS sorting.
ORGANISM(S): Mus musculus 
2008-11-25 | E-GEOD-13719 | biostudies-arrayexpress
TranscriptomicsAroA deficient Salmonella Typhimurium – More than an auxotrophic mutant
Recombinant attenuated Salmonella are believed to act as powerful live vaccine carrier able to elicit protection against many infectious agents. ∆aroA exhibits auxotrophy for aromatic amino acids and is commonly used for attenuation. Interestingly, deletion of aroA dramatically increased virulence...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2016-08-09 | E-GEOD-74433 | biostudies-arrayexpress
GenomicsExtensive Chromatin Remodeling and Establishment of Transcription Factor 'Hotspots' during Early Adipogenesis
Adipogenesis is tightly controlled by a complex network of transcription factors acting at different stages of differentiation. Peroxisome proliferator-activated receptor gamma (PPAR gamma) and CCAAT/enhancer binding protein (C/EBP) family members are key regulators of this process. We have employ...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-27826 | biostudies-arrayexpress
TranscriptomicsKnockout of the Acyl CoA binding protein (ACBP) in mice - expression profile from the liver of 21 days old ACBP-/- and +/+ mice.
The ACBP knockout were created by targeted disruption of the gene in mice. The expression profiling was performed on liver tissue from ACBP-/- (KO) and +/+ (WT) mice at the age of 21 days, which in our study is the time immediately before weaning. The mice used for this experiment were taken directl...
ORGANISM(S): Mus musculus 
2010-11-26 | E-GEOD-24451 | biostudies-arrayexpress
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