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ProteomicsLFQ-proteomic on bbs1 zebrafish photoreceptor outer segments
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal dystrophy, intellectual disability, polydactyly, obesity and renal anomalies. In photoreceptors (PR), light sensation occurs in outer segments (OSs), which are specialized primary cilia. BBS1, the major BBS gene, is part of a prote...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-02-10 | PXD026646 | Pride
Lfq-p Zebrafish Outer segment Photoreceptor Bbs 
ProteomicsWhole eye proteomic analysis of bbs1 zebrafish mutants
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal dystrophy, intellectual disability, polydactyly, obesity and renal anomalies. In photoreceptors (PR), light sensation occurs in outer segments (OSs), which are specialized primary cilia. BBS1, the major BBS gene, is part of a prote...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-02-10 | PXD030522 | Pride
Zebrafish Eye Bbs1 Lc-ms/ms 
MetabolomicsThe Bardet-Biedl protein Bbs1 controls photoreceptor outer segment protein and lipid composition

Summary

Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders such as Bardet-Biedl syndrome (BBS). Retinal degeneration is common in ciliopathies, since the outer segments (OSs) of photoreceptors are highly specialized primary cilia. BBS...

2022-02-18 | MTBLS4013 | MetaboLights
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