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ProteomicsOverexpression of catalase delays age-related cardiac disease by preventing oxidative cysteine modifications
Reactive protein cysteine thiolates are instrumental in redox regulation. Aging associated to oxidative stress, can impair redox signaling by damaging essential cysteine thiolates. Our initial study found that cardiac-specific overexpression of catalase, can protect from oxidative stress and delay c...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD002479 | Pride
Metabolism Proteomics Reversible cysteine thiol oxidation Tmt Post-translational protein modifications Mass spectrometry Cardiac aging and disease 
ProteomicsChanges in endothelial cell secretome after sirtuin-1 knock-down
Sirtuin1 (Sirt1) in skeletal muscle (SK) and fat protects against metabolic damage by stimulating insulin sensitivity. Here we report that mice with selective deletion of endothelial Sirt1 (E-Sirt1-KO) paradoxically exhibit heightened whole-body insulin sensitivity. Akt phosphorylation, glucose upta...
ORGANISM(S): Homo sapiens (Human) 
2023-08-07 | PXD030565 | Pride
Sirt1 Huvec Secretome 
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