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TranscriptomicsRole of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation
Previously, we have identified the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) gene as notably hypomethylated in low-malignant potential (LMP) and high-grade (HG) serous epithelial ovarian tumors, compared to normal ovarian tissues. Here we show that GALNT3 is strongly overexpressed in ...
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-52602 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human ovarian cancer cell lines grown as multicellular spheroids and treated with three chemotherapy drugs
Gene expression profiling of ovarian cancer spheroids upon treatment with three chemotherapy drugs
ORGANISM(S): Homo sapiens 
2008-05-06 | E-MEXP-1319 | biostudies-arrayexpress
TranscriptomicsLY75 modulates epithelial to mesenchymal transition and metastatic potential of ovarian cancer cells
Epithelial ovarian cancer (EOC) accounts for 4% of all cancers in women and is the leading cause of death from gynecologic malignancies. It is well established that cancer invasion and metastasis still represent the major causes of the failure of cancer treatment. Previously, we identified the manno...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-74711 | biostudies-arrayexpress
TranscriptomicsGene expression patterns of chemoresistant and chemosensitive serous epithelial ovarian tumors with possible predictive value in response to initial chemotherapy
Chemotherapy (CT) resistance in ovarian cancer is broad and encompasses diverse, unrelated drugs, suggesting more than one mechanism of resistance. We aimed to analyze the gene expression patterns in primary serous epithelial ovarian cancer (EOC) samples displaying different responses to first-line ...
ORGANISM(S): Homo sapiens 
2011-07-23 | E-GEOD-28739 | biostudies-arrayexpress
TranscriptomicsRole of malignant ascites on human mesothelial cells and their gene expression profiles
Background: Malignant ascites is often present at diagnostic in women with advanced ovarian cancer (OC) and its presence is associated with a worse outcome. Human peritoneal mesothelial cells (HPMCs) are key components of malignant ascites. Although the interplay between HPMCs and OC cells is believ...
ORGANISM(S): Homo sapiens 
2014-04-14 | E-GEOD-55065 | biostudies-arrayexpress
TranscriptomicsNUPR1 a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance
Sorafenib, an oral multikinase inhibitor, is the only approved agent for the treatment of advanced hepatocellular carcinoma (HCC). However, its benefits is modest, also because its mechanism of action remains elusive, therefore, a better understanding of its molecular action and molecular targets ar...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-73521 | biostudies-arrayexpress
TranscriptomicsInhibition of RUNX2 transcriptional activity blocks the proliferation, migration and invasion of epithelial ovarian carcinoma cells
Previously, we have identified the RUNX2 gene as hypomethylated and overexpressed in post-chemotherapy (CT) primary cultures derived from epithelial ovarian cancer (EOC) patients, when compared to primary cultures derived from matched primary (prior to CT) tumors. However, we found no differences in...
ORGANISM(S): Homo sapiens 
2013-09-23 | E-GEOD-46477 | biostudies-arrayexpress
TranscriptomicsCombination of celecoxib and sorafenib provides synergistic antiproliferative and proapoptotic effects in human liver cancer cells
Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although sorafenib is well tolerated, concern for its safety has been expressed. Cel...
ORGANISM(S): Homo sapiens 
2013-03-21 | E-GEOD-45340 | biostudies-arrayexpress
TranscriptomicsMouse embryonic kidneys (E13.5): HDAC inhibitor (HDACi) treated vs. Control
Transcriptional profiling of cultured CD1 mouse embryonic kidneys (E13.5) comparing HDACi-treated kidneys with control drug-treated kidneys. Studies in our lab showed that pharmacological inhibition of HDAC activity in ex-vivo cultured metanephroi results in extensive defects in kidney development,...
ORGANISM(S): Mus musculus 
2010-08-01 | E-GEOD-19581 | biostudies-arrayexpress
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