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ProteomicsPhosphosecretome profiling and kinase-substrate interaction screening reveal key extracellular c-Src-regulated pathways
Secreted protein kinases are responsible for the phosphorylation of a vast number of extracellular phosphoproteins. The tyrosine kinase c-Src is secreted through the vesicular trafficking pathway, however, mechanistic insights into extracellular substrate specificity and potential therapeutic opport...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-05-30 | PXD036069 | Pride
Post translational modification The tissue inhibitors of metalloproteinases Pxxp motif Src tyrosine kinase Timps Tumor growth inhibition Phosphoproteomic Blocking antibodies Secretome 
ProteomicsDeciphering PTM Crosstalk on Hsp90: Integrating Deep Learning for Drug Sensitivity Prediction
Post-translational modification (PTM) of proteins regulates cellular proteostasis by expanding protein functional diversity. This naturally leads to increased proteome complexity as the result of PTM crosstalk. Here, we used a heavily modified molecular chaperone, Heat shock protein-90 (Hsp90), to i...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD061927 | Pride
Hsp90 Ai Ganetespib Deep learning Hdac Acetylation Phosphorylation 
ProteomicsA specialized Hsp90 co-chaperone network regulates steroid hormone receptor response to ligand
Heat shock protein-90 chaperone machinery is involved in the stability and activity of its client proteins. The chaperone function of Hsp90 is regulated by co-chaperones and post-translational modifications. Although structural evidence exists for Hsp90 interaction with clients, our understanding of...
ORGANISM(S): Homo sapiens (Human) 
2023-05-30 | PXD030486 | Pride
Hsp90 Co-chaperone Chaperone Glucocorticoid receptor Tsc1 Fnip1 Fnip2 Steroid hormone receptors 
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