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GenomicsRNAseq analysis of skeletal muscle transcriptomes from wild-type, FNIP1-knockout (FNIP1-KO) mice, and mice expressing FNIP1 only in skeletal muscle (FNIP1-TgKO).
RNAseq analysis of skeletal muscle transcriptomes from wild-type, FNIP1-knockout (FNIP1-KO) mice, and mice expressing FNIP1 only in skeletal muscle (FNIP1-TgKO).
PRJNA631493 | ENA
ProteomicsCoIP-MS based method to identify FNIP1 binding proteins in exercising muscle
Using muscle-specific FNIP1 (WT) and FNIP1 (S220A Tg) muscle tissues, we identified approximately 600 potential FNIP1 (WT) or FNIP1 (S220A) binding proteins in exercising muscle tissue of the corresponding mice by the CoIP-MS method, proteomic analysis showed that both FNIP1 (WT) and FNIP1 (S220A) i...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-17 | PXD046977 | Pride
Mouse Coip. Muscle 
GenomicsRNAseq analysis of adipose tissue transcriptomes from wild-type and FNIP1 adipocyte specific knockout (FNIP1-AKO) mice
RNAseq analysis of adipose tissue transcriptomes from wild-type and FNIP1 adipocyte specific knockout (FNIP1-AKO) mice
PRJNA767577 | ENA
TranscriptomicsThe Folliculin-Fnip1 pathway deleted in human Birt-Hogg-Dube syndrome is required for B cell development.
Birt-Hogg-Dube (BHD) syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, cystic lung disease, and renal neoplasia. Affected individuals carry heterozygous mutations in Folliculin (FLCN), a tumor suppressor gene that becomes biallelically inactivated in kidney t...
ORGANISM(S): Mus musculus 
2012-06-16 | E-GEOD-38741 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of skeletal muscle transcriptomes from wild-type, FNIP1-knockout (FNIP1-KO) mice, and mice expressing FNIP1 only in skeletal muscle (FNIP1-TgKO).
This experiment was conducted to identify FNIP1-dependent mRNA transcripts alteration in skeletal muscle. Mouse FNIP1 was specifically overexpressed in skeletal muscle in FNIP1-transgenic (FNIP1-Tg) mice. FNIP1-Tg mice were crossed with FNIP1-knockout (FNIP1-KO) mice to generate FNIP1-TgKO mice expr...
ORGANISM(S): Mus musculus 
2021-03-17 | GSE150193 | GEO
ProteomicsPost-translational Regulation of FNIP1: a Rheostat for the Molecular Chaperone Hsp90
The molecular chaperone Hsp90 stabilizes and activates client proteins. Co-chaperones and post-translational modifications tightly regulate Hsp90 function and consequently lead to activation of clients. However, it is unclear whether this process occurs abruptly or gradually in the cellular context....
ORGANISM(S): Homo sapiens (Human) 
2019-01-31 | PXD012229 | Pride
Heat shock protein-90 (hsp90) Folliculin-interacting protein-1 O-glcnacylation Co-chaperone Fnip1 Pp5 Serine/threonine protein phosphatase-5 
TranscriptomicsRNAseq analysis of adipose tissue transcriptomes from wild-type and FNIP1 adipocyte specific knockout (FNIP1-AKO) mice
Activation of thermogenesis in brown and beige adipocytes upon activation by external stimuli burns fuel energy as heat. Owing to its remarkable benefits on metabolic health and its demonstrated presence in adult humans, beige adipocytes holds great promise to combat obesity and metabolic diseases. ...
ORGANISM(S): Mus musculus 
2022-02-26 | GSE185067 | GEO
TranscriptomicsMicroarray skeletal muscle miR-499 overexpressing mice
This experiment was conducted to identify target genes of the microRNA-499 in skeletal muscle of transgenic mice that overexpressed miR-499. The following abstract from the submitted manuscript describes the major findings of this work. Coupling of mitochondrial function and skeletal muscle f...
ORGANISM(S): Mus musculus 
2016-09-03 | E-GEOD-72581 | biostudies-arrayexpress
UnknownMetabolic regulator Fnip1 is crucial for iNKT lymphocyte development.
Not available
S-EPMC4024901 | biostudies-literature
TranscriptomicsFnip1 null kidney versus wildtype kidney RNAseq data
This RNAseq data was generated by comparing kidney tissue from Fnip1 null mice versus Wildtype Mice
ORGANISM(S): Mus musculus 
2018-05-15 | GSE103303 | GEO
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