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ProteomicsMechanism of client kinase dephosphorylation by the HSP90-CDC37-PP5 complex
Activation of client protein kinases by the HSP90 molecular chaperone system is affected by phosphorylation at multiple sites on HSP90, on the kinase specific co-chaperone CDC37, and the client itself. Removal of regulatory phosphorylation from client kinases and release from the HSP90-CDC37 system ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033678 | Pride
Kinase dephosphorylation Hsp90-cdc37-pp5 
ProteomicsMechanism of client kinase dephosphorylation by the HSP90-CDC37-PP5 complex
Activation of client protein kinases by the HSP90 molecular chaperone system is affected by phosphorylation at multiple sites on HSP90, on the kinase specific co-chaperone CDC37, and the client itself. Removal of regulatory phosphorylation from client kinases and release from the HSP90-CDC37 system ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035934 | Pride
M6a methylation Neuronal differentiation Imp1 regulation 
UnknownPP5 (PPP5C) is a phosphatase of Dvl2.
Not available
S-EPMC5807433 | biostudies-literature
ProteomicsIdentification of serine/threonine-specific phosphatases that dephosphorylate the co-chaperone BAG3 to mediate protein-protein interactions
Targeted phosphoproteomics of the human flag-tagged co-chaperone BAG3 to quantify phosphosite regulation by PP5.
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD050006 | Pride
Flag-ip Prm Bag3 Pp5 Hek293 Phosphorylation 
UnknownRac GTPase signaling through the PP5 protein phosphatase.
Not available
S-EPMC1458818 | biostudies-literature
ProteomicsSUMOylation of Protein Phosphatase 5 Regulates Phosphatase Activity and Substrate Release
The serine/threonine protein phosphatase 5 (PP5) regulates hormone and stress-induced signaling networks. PP5 has been suggested to exist largely in a ‘closed’ and autoinhibitory state whereas the ‘open’ conformation is required for activity. Additionally, PP5 is subject to post-translational modifi...
ORGANISM(S): Homo sapiens (Human) 
2023-09-08 | PXD038701 | Pride
Chaperone Ulk1 Chaperone code Hsp90 Atg1 Autophagy Phosphorylation 
UnknownHSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.
Not available
S-EPMC9709061 | biostudies-literature
UnknownHsp90 provides a platform for kinase dephosphorylation by PP5.
Not available
S-EPMC10110553 | biostudies-literature
UnknownExploration of the binding determinants of protein phosphatase 5 (PP5) reveals a chaperone-independent activation mechanism.
Not available
S-EPMC11259706 | biostudies-literature
UnknownNovel Ser/Thr protein phosphatase 5 (PP5) regulated targets during DNA damage identified by proteomics analysis.
Not available
S-EPMC2818885 | biostudies-literature
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