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ProteomicsULK1 phosphorylates and regulates mineralocorticoid receptor
To evaluate whether ULK1 phosphorylates mineralocorticoid receptor, we performed in vitro phosphatase assay and determined phosphorylation sites by mass spectrometry.
ORGANISM(S): None 
2018-07-17 | PXD010048 | JPOST Repository
ProteomicsActivation of autophagy depends on Atg1/ULK1 mediated phosphorylation of the chaperone Hsp90
The molecular chaperone Hsp90 is involved in the stability and activity of its client proteins which largely comprise of kinases. Phosphorylation of Hsp90 by these kinase clients provides a reciprocal regulatory mechanism between these proteins, however the mechanism of regulating the cellular pathw...
ORGANISM(S): Homo sapiens (Human) 
2023-09-08 | PXD038924 | Pride
Heat shock protein-90 (hsp90) Co-chaperone Serine/threonine protein phosphatase-5 (pp5) Sumoylation Molecular chaperone Phosphorylation 
ProteomicsULK1-dependent phosphorylation of RIPK1 within the intermediate domain
Mass-spectrometric analysis of an in vitro kinase assay using recombinant active ULK1 (Sigma-Aldrich, SRP5096) as kinase and GST-RIPK1(250-475) as substrate
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD018078 | Pride
Ulk1 Ripk1 
ProteomicsO-GlcNAcylation stabilizes ULK1 by inhibiting chaperone-mediated autophagy upon HPV infection
Human papillomaviruses (HPVs) are conducive to a fraction of head and neck squamous cell carcinoma (HNSCC). Previously we demonstrated that HPV16 oncogene E6 or E6/E7 transduction increases the abundance of O-linked GlcNAcylation (O-GlcNAc) transferase (OGT). Herein we focus on the effects of O-GlcN...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031095 | Pride
O-glcnac  ulk1  hpv  hnscc  macroautophagy  chaperone-mediated autophagy 
ProteomicsULK1 as a novel therapeutic target to enhance immune checkpoint therapies against melanoma
Immune checkpoint inhibitors (ICIs) have transformed the treatment of melanoma. However, the majority of patients have primary or acquired resistance to ICIs, limiting durable responses and patient survival. Interferon-gamma (IFNg) signaling and the expression of IFNg-stimulated genes correlate with...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD035347 | Pride
Irf1 Interferon-gamma Ulk1 Melanoma Pd-l1 Signaling Immune checkpoint inhibitors 
TranscriptomicsTranscriptional regulation of genes in AML12 cells treated with Palmitic acid, LXR lingand (GW3965) and Ulk1 siRNA
Transcriptional regulation of genes in AML12 cells treated with Palmitic acid, LXR lingand (GW3965) and Ulk1 siRNA shows differential effect of Ulk1 KD on LXr responsive genes AML-12 cells co-treated with 0.75mM PA+/- 10µM GW3965 for 24 h +/- Ulk1 SiRNA
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-74059 | biostudies-arrayexpress
TranscriptomicsCentral Role of ULK1 in Type I Interferon Signaling
We provide evidence that the Unc-51-like kinase 1 (ULK1) is phosphorylated and activated during engagement of the Type I IFN receptor. Our studies demonstrate that the function of ULK1 controls expression of key interferon stimulated genes (ISGs) that mediate important biological functions, includin...
ORGANISM(S): Mus musculus 
2014-08-26 | E-GEOD-60778 | biostudies-arrayexpress
ProteomicsULK1-dependent phosphorylation of RIPK1 within the intermediate domain
Mass-spectrometric analysis of an in vitro kinase assay using recombinant active ULK1 (Sigma-Aldrich, SRP5096) as kinase and GST-RIPK1(250-475) as substrate
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD018035 | Pride
Ulk1 Ripk1 
TranscriptomicsRNA-seq of HCT116 cells upon administration of FOLFOX or FOLFIRI at time points with or without ULK1 inhibitor
This experiment is aimed at studying the effect of two different chemotherapies (FOLFOX and FOLFIRI) and their interaction with a ULK1 inhibitor on HCT116 colorectal cancer cell line.
ORGANISM(S): Homo sapiens 
2023-09-01 | E-MTAB-12947 | biostudies-arrayexpress
ProteomicsULK1-Driven Autophagy Modulation Alters Tumor-Promoting Pathways in Triple-Negative Breast Cancer
This dataset supports a study investigating the proteomic consequences of pharmacological ULK1 modulation in triple-negative breast cancer. MDA-MB-231 cells were treated with the ULK1 activator LYN-1604 or the ULK1 inhibitor MRT68921 at EC50 concentrations (29.8 µM and 2.6 nM, respectively) for 24 h...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD072955 | Pride
Ulk1-driven autophagy modulation alters tumor-promoting pathways in triple-negative breast cancer 
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