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ProteomicsIdentification of serine/threonine-specific phosphatases that dephosphorylate the co-chaperone BAG3 to mediate protein-protein interactions
Targeted phosphoproteomics of the human flag-tagged co-chaperone BAG3 to quantify phosphosite regulation by PP5.
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD050006 | Pride
Flag-ip Prm Bag3 Pp5 Hek293 Phosphorylation 
ProteomicsIdentification of phosphorylation sites of BAG3
HEK293 cells were cultured in two 10-cm dishes and transfected with BAG3-FLAG as well as Myc vector, CaMKIIβ(D-S)-Myc, and CaMKIIδ(D-S)-MYC, respectively. After the cells were transfected for 24 h, they were treated with the indicated regent. The cells were lysed with NP-40 alternative cell lysis bu...
ORGANISM(S): Homo sapiens (Human) 
2024-08-20 | PXD054722 | Pride
Phosphorylation sites Bag3 Human 
ProteomicsIdentification of serine/threonine-specific phosphatases that dephosphorylate the co-chaperone BAG3 to mediate protein-protein interactions
AP-MS study of the human flag-tagged co-chaperone BAG3 and phospho-mimicking mutants (D/A) to identify phosphorylation-dependent changes in binding.
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD057392 | Pride
Ap-ms Flag-ip Bag3 Pp5 Hek293 
GenomicsBag3-P209L RNA Seq Project
Bag3-P209L RNA Seq Project
PRJNA477769 | ENA
ProteomicsBAG3 regulates cilia homeostasis of glioblastoma via its WW domain
The multidomain protein BAG3 exerts pleiotropic oncogenic functions in many tumor entities including glioblastoma (GBM). Here we compared BAG3 protein-protein interactions in either adherently cultured or stem-like cultured U251 GBM cells. In line with BAG3´s putative role in stemness, identified in...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD050279 | Pride
Cilia homeostasis Stemness Yap1 Ww domain Glioblastoma Bag3 Yap1 signaling Primary cilia 
GenomicsErythranthe guttata cultivar:tilingii BAG3
Erythranthe guttata cultivar:tilingii BAG3 Genome sequencing
PRJNA337397 | ENA
ProteomicsIdentification of serine/threonine-specific phosphatases that dephosphorylate the co-chaperone BAG3 to mediate protein-protein interactions
AP-MS study of the human flag-tagged co-chaperone BAG3 to identify putative phosphatases which can regulate BAG3 function. From the two hits PP1 and PP5, the later was confirmed in a reverse AP-MS experiment. PLEASE NOTE THAT ONLY THE FILES LABELLED 'CORRECTED' BELONG TO THIS DATASET
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD050035 | Pride
Ap-ms Flag-ip Bag3 Pp5 Hek293 
ProteomicsChronic intermittent autophagy inhibition ameliorates Bag3-dependent cardiomyopathy
Mutations in the Hsp70 co-chaperone Bcl2-associated athanogene 3 (Bag3) result in myofibrillar myopathy and pediatric hypertrophic cardiomyopathy (pHCM) in human patients, but the pathological mechanisms underlying Bag3 dysfunction in the developing heart have remained unclear. Here we show that con...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-05 | PXD016095 | Pride
Chloroquine Cx43 Bag3 Pediatric hypertrophic cardiomyopathy (phcm) Autophagy Protein quality control 
ProteomicsInteractome of overexpressed BAG3 in HEK293T cells
HEK293T cells stably expressing N-terminally HA-tagged BAG3 were employed to screen for novel BAG3 interacting proteins.
ORGANISM(S): Homo sapiens (Human) 
2019-10-10 | PXD014473 | Pride
Ha-ip Bag3 Ltq velos 
TranscriptomicsIdentification of genes involved in enhancement of hyperthermia sensitivity by knockdown of BAG3 in human oral squamous cell carcinoma cells
Hyperthermia (HT) treatments in combination with either chemotherapy, radiotherapy or both are used for patients with cancer in various organs. However, the acquisition of thermotolerance in cancer cells due to the increase in cytoprotective proteins attenuates the therapeutic effects of HT. BAG3 (B...
ORGANISM(S): Homo sapiens 
2015-11-19 | E-GEOD-75127 | biostudies-arrayexpress
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