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MetabolomicsMetabolite of esculetin plays an important role in cytotoxic effects induced by chloroquine on porcine immature Sertoli cells

Chloroquine (CQ) is widely used in the therapy against malarial, tumor and recently the COVID-19 pandemic, as a lysosomotropic agent to inhibit the endolysosomal trafficking in the autophagy pathway. We previously reported that CQ (20 µM, 36 h) could reprogram transcriptome and impair multiple si...

2024-07-08 | MTBLS9273 | MetaboLights
TranscriptomicsPotentiation of glucocorticoid signaling by chloroquine via inhibition of lysosomes
Anti-malaria drug chloroquine has been used as an anti-inflammatory agent for treating systemic lupus erythematosus and rheumatoid arthritis, without clear mechanism of action. Here we report that chloroquine potently inhibits the expression of proinflammatory cytokines through transrepression of g...
ORGANISM(S): Homo sapiens 
2012-01-18 | E-GEOD-24579 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of female Anopheles gambiae mosquitoes blood fed on mice infected with P. berghei and treated with chloroquine or untreated
The effect of chloroquine on mosquitoes transcript abundance was assayed by comparing gene expression between mosquitoes fed on a blood meal containing 50 mg/Kg of chloroquine and those that had fed on a normal blood meal. Pools of 50 midguts were dissected and were hybridize with MMC1 (or 20K) micr...
ORGANISM(S): Anopheles gambiae 
2007-10-12 | E-MEXP-1201 | biostudies-arrayexpress
TranscriptomicsACTG A5258 Clinical administration of chloroquine to HIV-infected patients receiving antiretroviral therapy to reduce immune activation
ACTG A5258, we asked whether chloroquine could reduce the immune activation in HIV infection posited to be driven by microbial TLR agonists, such as bacterial elements translocated from the gut and HIV-1 RNAs . We anticipate that blocking this activation pathway might interfere with events in patho...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-71064 | biostudies-arrayexpress
TranscriptomicsACTG A5258 Clinical administration of chloroquine to patients with untreated chronic HIV infection to reduce immune activation
ACTG A5258, we asked whether chloroquine could reduce the immune activation in HIV infection posited to be driven by microbial TLR agonists, such as bacterial elements translocated from the gut and HIV-1 RNAs . We anticipate that blocking this activation pathway might interfere with events in patho...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-71063 | biostudies-arrayexpress
TranscriptomicsPyronaridine and chloroquine responses in the K1 strain
Pyronaridine (PN) and chloroquine (CQ) are structurally related anti-malarial drugs with primarily the same mode of action. However, PN is effective against several multidrug-resistant lines of Plasmodium falciparum, including CQ-resistant lines, suggestive of important operational differences betwe...
ORGANISM(S): Plasmodium falciparum 
2011-08-01 | E-GEOD-30867 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of the antiviral effect of chloroquine and derivatives on in vitro HCV infected cells.
The main goal of this study is to characterize the transcriptional modulations induced by antiviral compounds derived from chloroquine on Huh7 cells infected with HCV. And thus to identify among the genes modulated by infection, those who are regulated by chloroquine and potentially involved in the ...
ORGANISM(S): Homo sapiens 
2012-06-30 | E-GEOD-30351 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human cell line U2OS treated with chloroquine, amodiaquine and BMH-21
Ribosome biogenesis has emerged as a potential target for cancer therapy. We have characterize a new biological activity of the antimalarial drug amodiaquine as a inhibitor of ribosome biogenesis. Interestingly, amodiaquine retains the autophagy inhibitory activity of its analog chloroquine, but in ...
ORGANISM(S): Homo sapiens 
2019-09-01 | E-MTAB-7616 | biostudies-arrayexpress
TranscriptomicsStructural polymorphism in the promoter of pfmrp2 confers tolerance to mefloquine and chloroquine in Plasmodium falciparum [expression]
Drug resistance in Plasmodium falciparum remains a challenge for the malaria eradication programs around the world. With the emergence of artemisinin resistance, the efficacy of the partner drugs in the artemisinin combination therapies (ACT) that include quinoline based drugs is becoming critical. ...
ORGANISM(S): Plasmodium falciparum 
2013-02-07 | E-GEOD-44127 | biostudies-arrayexpress
TranscriptomicsStructural polymorphism in the promoter of pfmrp2 confers tolerance to mefloquine and chloroquine in Plasmodium falciparum [CGH]
Drug resistance in Plasmodium falciparum remains a challenge for the malaria eradication programs around the world. With the emergence of artemisinin resistance, the efficacy of the partner drugs in the artemisinin combination therapies (ACT) that include quinoline based drugs is becoming critical. ...
ORGANISM(S): Plasmodium falciparum 
2013-02-07 | E-GEOD-44128 | biostudies-arrayexpress
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