104828 Results

Show all   Save search   Copy query
Sort   by:  
 Page size 
MetabolomicsSkeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves
The effects of different amino acid (AA) supplementations of milk protein-based milk replacers in pre-ruminant calves from 3 days to 7 weeks of age were studied. Animals were divided into 4 groups: Ctrl) Control group fed with milk protein-based milk replacer without supplementation; GP) supplementa...
2018-10-08 | MTBLS720 | MetaboLights
MetabolomicsGenomic and lipidomic actions of nandrolone on detached rotator cuff muscle in sheep
Reversal of fatty infiltration of pennate rotator cuff muscle after tendon release is hitherto impossible. The administration of nandrolone starting at the time of tendon release prevents the increase in fat content, but does not revert established fatty infiltration. We hypothesised that tendon rel...
2017-07-14 | MTBLS322 | MetaboLights
MetabolomicsMetabolome and proteome changes in skeletal muscle and blood of pre-weaning calves fed leucine and threonine supplemented diets

In pre-weaning calves, both leucine and threonine play important roles in growth and muscle metabolism. In this study, metabolomics, proteomics and clinical chemistry were used to assess the effects of leucine and threonine supplementation added to milk replacer on 14 newborn Holstein male calves...

2020-02-20 | MTBLS1045 | MetaboLights
MetabolomicsResponse to dietary carbohydrates in European seabass (Dicentrarchus labrax) muscle tissue as revealed by NMR-based metabolomics

INTRODUCTION: Feed optimization is a key step to the environmental and economic sustainability of aquaculture, especially for carnivorous species. Plant-derived ingredients can contribute to reduce costs and nitrogenous effluents while sparing wild fish stocks. However, the metab...

2019-01-22 | MTBLS619 | MetaboLights
MetabolomicsClenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β2-adrenergic receptor agonists results in multiple beneficial metabolic effects, including improved glucose homeostasis. To...
2022-08-26 | MTBLS467 | MetaboLights
MetabolomicsPhotosynthetic bioenergetic-redox restoration rejuvenates the aged muscle regenerative niche

Aging impairs muscle regeneration, but the key constraint remains unclear. Aged injured muscle fails to restore mitochondrial respiration, membrane potential, ATP/NADPH balance and redox control, forming a bioenergetic-redox bottleneck. To target this, we engineered CM-NTU-Ce, a C2C12 membrane-co...

2026-08-13 | MTBLS15312 | MetaboLights
MetabolomicsMulti-omics Insights into Postnatal Skeletal Muscle Development in Duroc Pigs

Skeletal muscles, accounting for 40% of mammalian body mass, exhibit pronounced heterogeneity due to distinct anatomical locations. Animal husbandry excessively focuses on longissimus dorsi (LDM) development, while neglecting other muscles. In this study, we integrated Bulk RNA Sequencing (bulk R...

2025-09-09 | MTBLS12963 | MetaboLights
MetabolomicsGSDME-controlled pyroptosis promotes muscle repair by coordinating tissue resident macrophages and fibro-adipogenic progenitors
GSDME (Gasdermin E) is a critical protein known for its role in pyroptosis, a form of programmed cell death associated with inflammation. We demonstrated that GSDME as a crucial mediator in muscle repair, particularly in the context of muscle damage induced by cardiotoxin (CTX). Specifically, we fou...
2026-01-05 | MTBLS10509 | MetaboLights
MetabolomicsExercise-Associated Microbial Metabolites Prevent Skeletal Muscle Atrophy in Adult Mice
We previously reported that skeletal muscle adaptation to regular exercise requires a healthy gut microbiome, contributing to growing evidence that some exercise benefits are mediated by microbiome-derived metabolites. Here, to identify such exercise-associated microbial metabolites, we transfer cec...
2026-05-27 | MTBLS14386 | MetaboLights
MetabolomicsMulti-omic responses of mouse liver and skeletal muscle to chronic alcohol drinking

The aim of this study was to define and compare the molecular blueprints of chronic alcohol use in the liver and skeletal muscle using an established pre-clinical mouse model.

2025-12-11 | MTBLS12616 | MetaboLights
Sort   by:  
 Page size