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MetabolomicsThe metabolic background is a global player in Saccharomyces gene expression epistasis
The regulation of gene expression in response to nutrient availability is fundamental to the genotype-phenotype relationship. The metabolic-genetic make-up of the cell, as reflected in auxotrophy, is hence likely to be a determinant of gene expression. Here, we address the importance of the metaboli...
2016-12-16 | MTBLS168 | MetaboLights
MetabolomicsGenetic background shapes phenotypic response to diet for adiposity in the Collaborative Cross
Not available
ORGANISM(S): Mus musculus 
ST001607 | MetabolomicsWorkbench
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
ProteomicsDecreasing Protein Biotinylation Background in a Diatom Facilitates Proximity Labeling of the Periplastidial Compartment Proteome
Diatoms are ecologically and industrially significant microalgae, crucial for global carbon fixation and biotechnological applications. Their complex plastid membrane structures, resulting from secondary endosymbiosis, remain poorly characterized, particularly the periplastidial compartment (PPC). P...
ORGANISM(S): Homo Sapiens Oryza Sativa Nicotiana Benthamiana Nannochloropsis Oceanica Thalassiosira Pseudonana Arabidopsis Thaliana Phaeodactylum Tricornutum 
2025-03-14 | PXD061818 |
TranscriptomicsMicroarray of five Caenorhabiditis elegans genotypes with or without a human alpha-synuclein transgene in the genetic background
Previous studies in Caenorhabditis elegans expressing the human alpha-synuclein protein, have shown that protein aggregation and some aetiologies of Parkinsons disease can be recapitulated in this model nematode. However, it is known that the genetic background is important in how the disease progre...
ORGANISM(S): Caenorhabditis elegans 
2019-02-11 | E-MTAB-6960 | biostudies-arrayexpress
TranscriptomicsRegulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background
Transcriptional profiling of E14.5 XY germ cells (marked with Oct4-EGFP transgene) from two strain backgrounds (C57BL/6J and 129S1/SvImJ) that differ in their susceptibility to testicular teratomas. Two condition experiment. For each sample, Oct4-EGFP+ germ cells from all XY embyos within a litter w...
ORGANISM(S): Mus musculus 
2010-12-22 | E-GEOD-24340 | biostudies-arrayexpress
ProteomicsA whole proteome inventory of background photocrosslinker binding
Affinity based protein profiling (AfBPP) is a widely applied methodology for target identification of bioactive molecules. Photocrosslinkers such as benzophenone, diazirine and aryl azide irreversibly link the molecule of interest to its dedicated target protein upon irradiation with UV light. Despi...
ORGANISM(S): Homo sapiens (Human) 
2016-12-05 | PXD004009 | Pride
Affinity-based protein profiling Photocrosslinker Target identification 
TranscriptomicsProtein P Vs Protein G
Rationale: Respiratory syncytial virus (RSV) and Streptococcus pneumoniae are major respiratory pathogens. Co-infection with RSV and S. pneumoniae is associated with severe and often fatal pneumonia but the molecular basis for this remains unclear. Objectives: To determine if interaction between RS...
ORGANISM(S): Streptococcus pneumoniae D39 
2014-06-21 | E-GEOD-58424 | biostudies-arrayexpress
ProteomicsComparison of DIA and TMT based protein quantification in complex background
Label free quantification (LFQ) and isobaric labelling quantification (ILQ) are among the most popular protein quantification workflows in discovery proteomics. Here, we compared the TMT 10-plex workflow to label free single shot data-independent acquisition (DIA) method on a controlled sample set. ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-01-29 | MSV000084859 | MassIVE
TranscriptomicsGenomic consequences of background effects on scalloped mutant expressivity in the wing of Drosophila
Genetic background effects contribute to the phenotypic consequences of mutations, and are pervasive across all domains of life that have been examined, yet little is known about how they modify genetic systems. In part this is due to the lack of tractable model systems that have been explicitly de...
ORGANISM(S): Drosophila melanogaster 
2010-05-15 | E-GEOD-13779 | biostudies-arrayexpress
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