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ProteomicsA whole proteome inventory of background photocrosslinker binding
Affinity based protein profiling (AfBPP) is a widely applied methodology for target identification of bioactive molecules. Photocrosslinkers such as benzophenone, diazirine and aryl azide irreversibly link the molecule of interest to its dedicated target protein upon irradiation with UV light. Despi...
ORGANISM(S): Homo sapiens (Human) 
2016-12-05 | PXD004009 | Pride
Affinity-based protein profiling Photocrosslinker Target identification 
UnknownA trifunctional probe for generation of fluorogenic glycan-photocrosslinker conjugates.
Not available
S-EPMC12459285 | biostudies-literature
UnknownGenetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label.
Not available
S-EPMC4974458 | biostudies-literature
UnknownHigh-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology.
Not available
S-EPMC8448361 | biostudies-literature
ProteomicsIdentification of Mono-ADP-Ribose Readers Using Well-Defined Photoaffinity-based Probes
In this study, well-defined photoaffinity-based monoADPr probes (biotin-linked) were synthesized and used to study direct interactors of monoADPr. Either a benzophenone or diazirine group was incorporated to assess their performance in enriching for known mnonoADPr readers. To ensure only monoADPr r...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD065574 | Pride
Astral Monoadpr Adp-ribosylation 
UnknownTranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping.
Not available
S-EPMC8341850 | biostudies-literature
UnknownChemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor.
Not available
S-EPMC7403387 | biostudies-literature
UnknownRoom temperature 3D printing of super-soft and solvent-free elastomers.
Not available
S-EPMC7673745 | biostudies-literature
UnknownEvidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.
Not available
S-EPMC4740876 | biostudies-literature
ProteomicsTranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping
Monoamine oxidases MAOA and MAOB catalyze important cellular functions such as the deamination of neurotransmitters. Correspondingly, MAO inhibitors are used for the treatment of severe neuropsychiatric disorders such as depression. A commonly prescribed drug against refractory depression is tranylc...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD018580 | Pride
Human Abpp Lc-ms/ms 
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