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ProteomicsActivity-based profiling of deubiquitylating enzymes
This set is a repackaging of PXD031848 (described in https://doi.org/10.3390/ijms23063263: "ABPP-HT*-Deep Meets Fast for Activity-Based Profiling of Deubiquitylating Enzymes Using Advanced DIA Mass Spectrometry Methods") to make each LC-MS/MS experiment individually downloadable and to include TIMSC...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-07-24 | MSV000095426 | MassIVE
ProteomicsCIMAGE2.0: An Expanded Tool for Quantitative Analysis of Activity-based Probe Profiling (ABPP) Data
Activity-based Protein Profiling (ABPP) is a powerful chemo-proteomic method to study proteins’ activity, modifications and interactions in a high-throughput manner. In ABPP experiments, accurate quantification is crucial to determine the extent of probe labeling at the level of either target protei...
ORGANISM(S): Homo Sapiens 
2021-03-16 | PXD024754 |
ProteomicsDegrasyn exhibits antibiotic activity against multi-resistant Staphylococcus aureus by modifying several essential cysteines
In this dataset, we investigate the targets of degrasyn in the methicillin-sensitive S. aureus strain NCTC 8325. This includes data on enrichment studies and competition studies with conventional ABPP using a degrasyn-derived probe, competition studies with residue-specific proteomics using the isoD...
ORGANISM(S): Staphylococcus aureus 
2020-04-14 | PXD016413 | Pride
Chemoproteomics Antibioitcs S. aureus Isodtb-abpp 
ProteomicsABPP-HT* - Deep meets fast for activity-based profiling of deubiquitylating enzymes using advanced DIA mass spectrometry methodsABPP-HT* - Deep meets fast for activity-based profiling of deubiquitylating enzymes using advanced DIA mass spectrometry methods
Activity-based protein profiling (ABPP) uses a combination of activity-based chemical probes with mass spectrometry (MS) to selectively characterise a particular enzyme or enzyme class. ABPP has proven invaluable for profiling enzymatic inhibitors in drug discovery. When applied to cell extracts and...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD031848 | Pride
Data-independent acquisition mass spectrometry (dia) Drug discovery Proteomics Activitomics Mass spectrometry Chemical biology Deubiquitylating enzymes Ubiquitin Activity-based probes 
ProteomicsIdentification of sulfhydryl-containing proteins and further evaluation of the selenium- tagged redox homeostasis-regulating proteins:Identification of cysteine sites using tandem orthogonal proteolysis strategy (TOP-ABPP).
We sought to identify exact modified cysteine sites by Se-probes using TOP-ABPP strategy and the acid cleavable azide-biotin tag was used to enrich and release the modified peptides for LC-MS/MS analys
ORGANISM(S): Homo sapiens (Human) 
2023-12-07 | PXD046852 | Pride
Top-abpp npspyne npssyne dpdsyne 
UnknownABPP-HT*-Deep Meets Fast for Activity-Based Profiling of Deubiquitylating Enzymes Using Advanced DIA Mass Spectrometry Methods.
Not available
S-EPMC8955990 | biostudies-literature
UnknownPGAT-ABPp: harnessing protein language models and graph attention networks for antibacterial peptide identification with remarkable accuracy.
Not available
S-EPMC11338452 | biostudies-literature
UnknownABPP-HT - High-Throughput Activity-Based Profiling of Deubiquitylating Enzyme Inhibitors in a Cellular Context.
Not available
S-EPMC7947856 | biostudies-literature
ProteomicsTMT-ABPP profiling of SP3CHO in native 293T proteome
This TMT-ABPP experiment was performed in native 293T proteome treated with a range of concentrations of SP3CHO compounds.
ORGANISM(S): Homo sapiens (Human) 
2024-06-24 | PXD051803 | Pride
Abpp Tmt Chemoproteomic 
UnknownSelective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP.
Not available
S-EPMC3634566 | biostudies-literature
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