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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
TranscriptomicsTranscriptomes and differential gene expression analysis of the Arabidopsis cells that received type-III effectors delivered by Xanthomonas campestris pv. Campestris (Xcc) bacterial mutants
Due to low numbers and poor accessibility of host cells that are targeted for effector delivery, the actual biological functions of most effectors remain elusive. Here, we developed a novel Isolation Nuclei TArgeted by Bacterial Effectors (INTABE) system, which facilitates selectively recovering nuc...
ORGANISM(S): Arabidopsis thaliana 
2022-10-22 | E-MTAB-10280 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD8 naive (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells
Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naïve (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression microarrays and phospho-protein-specific i...
ORGANISM(S): Homo sapiens 
2005-01-01 | E-TABM-40 | biostudies-arrayexpress
GenomicsChIP-Seq analysis of BATF, IRF4, the Jun proteins, and histone modifications in effector CD8+ T cells
The transcription factor BATF is required for Th17 and TFH differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastr...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54191 | biostudies-arrayexpress
MetabolomicsDecreased abundance of type III secretion systeminducing signals in Arabidopsis mkp1 enhances resistance against Pseudomonas syringae
Genes encoding the virulence-promoting type III secretion system (T3SS) in phytopathogenic bacteria are induced at the start of infection, indicating that recognition of signals from the host plant initiates this response. However, the precise nature of these signals and whether their concentrations...
2014-06-24 | MTBLS95 | MetaboLights
TranscriptomicsTranscription profiling of human Caco-2 intestinal epithelial cell line infected with wild type Shigella flexneri and a OspF mutantt reveals an injected bacterial effector targets chromatin access for NF-kB as a strategy to shape transcription of immune genes
Phosphorylation of histone H3 at Serine 10 emerges as a mechanism increasing chromatin accessibility of the transcription factor NF-kB for a particular set of immune genes. Here we report that a bacterial pathogen uses this strategy to shape the transcriptional response of infected host cells. We id...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6082 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of naïve and in vitro effector CD8+ T cells from wild-type and BATF-/- mice
The transcription factor BATF is required for Th17 and TFH differentiation. Here, we show that BATF also has a fundamental role in regulating effector CD8+ T cell differentiation. BATF-deficient CD8+ T cells show profound defects in effector expansion and undergo proliferative and metabolic catastr...
ORGANISM(S): Mus musculus 
2014-03-02 | E-GEOD-54215 | biostudies-arrayexpress
TranscriptomicsHost transcriptional reprogramming in response to the rice bacterial blight pathogen Xanthomonas oryzae pv.oryzae constitutively expressing the X. oryzae pv. oryzicola TAL2a effector from the high copy vector pKEB31
We performed RNA-Seq of leaves of Oryza sativa L. ssp. japonica cv. Nipponbare 48 hours after inoculation with  Xanthomonas oryzae pv. oryzae strain PXO99A heterologously expressing the Tal2a effector, the designer TAL effector dT280 which targets a sequence overlapping the predicted Tal2a binding s...
ORGANISM(S): Oryza sativa Japonica Group 
2015-05-01 | E-GEOD-67958 | biostudies-arrayexpress
ProteomicsGlobal mapping of Salmonella enterica-host protein-protein interactions during infection
Intracellular bacterial pathogens inject a cocktail of effector proteins into host cells to hijack diverse cellular processes and promote their survival and proliferation. Salmonella enterica serovar Typhimurium (STm) uses two Type 3 secretion system (T3SS) to deliver a suite of effector proteins in...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-06-25 | PXD018375 | Pride
Bacterial pathogen Salmonella Effectors Ap/ms 
GenomicsTDRD3 is an effector molecule for arginine methylated histone marks
Specific sites of histone tail methylation are associated with transcriptional activity at gene loci. These methyl-marks are interpreted by effector molecules, which harbor protein domains that bind the methylated motifs and facilitate either active or inactive states of transcription. CARM1 and PRM...
ORGANISM(S): Homo sapiens 
2011-01-06 | E-GEOD-22612 | biostudies-arrayexpress
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