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MetabolomicsProteolytic-Resistant Self-Assembling Peptide Nanofibers Combat Specific Bacterial Infections via Trap-and-Kill

The rise in global antibiotic resistance highlights the urgent need for effective antimicrobial agents. Antimicrobial peptides (AMPs) offer a potential solution to combat bacterial resistance. However, key challenges remain in addressing the limitations of current peptide drugs and biomaterials, ...

2025-06-13 | MTBLS12424 | MetaboLights
TranscriptomicsMapping and characterization of promoter-binding sites of protein phosphatase 1
Protein phosphatase 1 (PP1) is a Ser/Thr phosphatase that has been implicated in many key cellular functions including transcriptional regulation. Due to its involvement these many processes, it becomes difficult to directly link PP1 to transcriptional regulation on the chromatin level as no direct ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-54170 | biostudies-arrayexpress
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
TranscriptomicsTranscriptional profiling of Rapamycin treatment in yeast cells lacking the Ptc1 protein phosphatase.
We are interested in the study of the already reported sensitivity of yeast cells lacking the type 1 protein phosphatase Ptc1 to the drug rapamycin. In order to carry out our studies, we analyzed the changes in the transcription profile that a short-term incubation with rapamycin (200 ng/mL) has in ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-31 | E-GEOD-11530 | biostudies-arrayexpress
MetabolomicsDecreased abundance of type III secretion systeminducing signals in Arabidopsis mkp1 enhances resistance against Pseudomonas syringae
Genes encoding the virulence-promoting type III secretion system (T3SS) in phytopathogenic bacteria are induced at the start of infection, indicating that recognition of signals from the host plant initiates this response. However, the precise nature of these signals and whether their concentrations...
2014-06-24 | MTBLS95 | MetaboLights
TranscriptomicsWidespread Occurrence of m6A in bacterial mRNA
N6-methyladenosine (m6A) is one of the most abundant modifications in eukaryotic RNA. Recent mapping of m6A methylomes in mammals, yeast, and plants as well as characterization of m6A methyltransferases, demethylases, and binding proteins have revealed regulatory functions of this dynamic RNA modifi...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2015-07-08 | E-GEOD-65347 | biostudies-arrayexpress
TranscriptomicsProtein P Vs Protein G
Rationale: Respiratory syncytial virus (RSV) and Streptococcus pneumoniae are major respiratory pathogens. Co-infection with RSV and S. pneumoniae is associated with severe and often fatal pneumonia but the molecular basis for this remains unclear. Objectives: To determine if interaction between RS...
ORGANISM(S): Streptococcus pneumoniae D39 
2014-06-21 | E-GEOD-58424 | biostudies-arrayexpress
UnknownKinetic and structural analysis of a bacterial protein tyrosine phosphatase-like myo-inositol polyphosphatase.
Not available
S-EPMC2206706 | biostudies-literature
TranscriptomicsTranscription profiling of human Caco-2 intestinal epithelial cell line infected with wild type Shigella flexneri and a OspF mutantt reveals an injected bacterial effector targets chromatin access for NF-kB as a strategy to shape transcription of immune genes
Phosphorylation of histone H3 at Serine 10 emerges as a mechanism increasing chromatin accessibility of the transcription factor NF-kB for a particular set of immune genes. Here we report that a bacterial pathogen uses this strategy to shape the transcriptional response of infected host cells. We id...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6082 | biostudies-arrayexpress
UnknownThree-dimensional structure and ligand interactions of the low molecular weight protein tyrosine phosphatase from Campylobacter jejuni.
Not available
S-EPMC2242389 | biostudies-literature
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