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GenomicsiMUT-seq analysis of over 20 different DSB repair siRNA mediated knockdowns or small molecule inhibitors
iMUT-seq profiles double-strand break (DSB) induced mutations at extremely high sensitive with single nucleotide resolution, allowing for the quantification of all mutation types, including chromosomal rearrangements, around endogenous DSBs. AID-DIvA cells are treated with or without 4-hydroxytamox...
ORGANISM(S): Homo sapiens 
2022-11-25 | E-MTAB-11259 | biostudies-arrayexpress
GenomicsDNA-Protein Crosslink sequencing (DPC-seq) in RPE-1 cells treated with formaldehyde
Covalent DNA-protein crosslinks (DPC) are toxic DNA lesions that require repair by global-genome and replication-coupled pathways. How cells respond when RNA polymerases stall at DPCs during transcription is unknown. DPC-seq is new method for the genome-wide mapping of covalent DNA-protein adducts.
ORGANISM(S): Homo sapiens 
2024-02-24 | E-MTAB-12912 | biostudies-arrayexpress
UnknownLoss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay
Not available
S-SCDT-10_1038-S44321-025-00352-X | biostudies-other
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