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TranscriptomicsRobust Molecular Classification of Ependymal Tumors Across All Anatomic Compartments
Ependymal tumors across age groups have been classified solely by histopathology. It is, however, commonly accepted that this classification has limited clinical utility based on its poor reliability. We aimed at establishing a reliable and reproducible molecular classification using DNA methylation...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-65362 | biostudies-arrayexpress
UnknownQuiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.
Not available
S-EPMC4441014 | biostudies-literature
TranscriptomicsMethylation profiling data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-49377 | biostudies-arrayexpress
GenomicsGenetic landscape of pediatric Medulloblastoma
Medulloblastoma is a heterogenous disease made up of at least four distinct subtypes of disease which appear to exploit and disrupt naturally occurring developmental pathways of cellular growth and hindbrain development. To better understand the driver mutations of this disease, we performed whole g...
EGAS00001000347 | EGA
Genomics2013-11-19-17-24-36-breez-MB-2013-10-18-Whole_exome_DNAseq_Medulloblastoma - samples
Illumina HiSeq sequence data (with >80x coverage) were aligned to the hg19 human reference genome assembly using BWA (Li and Durbin, 2009); duplicate reads were removed from the final BAM file. No realignment or recalibration was performed. The whole exome sequencing data of 20 SHH medulloblastomas ...
EGAD00001000698 | EGA
UnknownSpatial heterogeneity in medulloblastoma.
Not available
S-EPMC5553617 | biostudies-literature
GenomicsSHH medulloblastoma samples
Sequencing data of human SHH medulloblastoma samples
EGAS00001000607 | EGA
GenomicsPCGP MB WGS Full - samples
DATA FILES FOR PCGP MB WGS - Supersedes (EGAD00001000269)
EGAD00001001864 | EGA
GenomicsPCGP MB - samples
OLD DATA FILES FOR SJMB - Superseded by EGAD00001001864
EGAD00001000269 | EGA
TranscriptomicsSubgroup specific somatic copy number aberrations in the medulloblastoma genome [gDNA]
Affymetrix SNP6 profiling of 1087 medulloblastoma samples and 10 medulloblastoma cell lines. Genomic DNA was extracted from primary medulloblastoma samples and medulloblastoma cell lines and hybridized to Affymetrix SNP6 arrays according to the manufacturer's instructions.
ORGANISM(S): Homo sapiens 
2012-07-26 | E-GEOD-37384 | biostudies-arrayexpress
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