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Herein, we explore the druggability of BAG-1S (the smallest isoform) with a specific emphasis on its interaction with C-RAF. We firstly characterize the higher order structure of BAG-1S structure to determine druggable sites by HDX-MS. We then map the BAG-1S:c-Raf interface – identifying a 20 amino ...
ORGANISM(S): Homo sapiens (Human) 
2024-12-17 | PXD058656 | Pride
RNA-seq profiling of BAG neurons in C. elegans npr-1 and npr-1 arcp-1 animals
In order to improve therapy for head and neck squamous cell carcinoma (HNSCC), biomarkers associated with local and/or distant tumor relapses and cancer drug resistance are urgently needed. This study identified a potential biomarker, BAG-1 (Bcl-2 associated athanogene-1), that is implicated in HNSC...
ORGANISM(S): Homo sapiens 
2017-10-04 | GSE102787 | GEO
The extent to which behavior is shaped by experience varies between individuals. Genetic differences contribute to this variation but the neural mechanisms are not understood. In this study, we identify a natural genetic variant of the dendritic scaffolding protein ARCP-1 that modifies individual be...
ORGANISM(S): Caenorhabditis elegans 
2019-11-19 | GSE135687 | GEO
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