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TranscriptomicsResponse of Prochlorococcus to varying CO2:O2 ratios
Carbon fixation plays a central role in determining cellular redox poise, increasingly understood to be a key parameter in cyanobacterial physiology. In the cyanobacterium Prochlorococcus--—the most abundant phototroph in the oligotrophic oceans--—the carbon-concentrating mechanism (CCM) is reduced...
ORGANISM(S): Prochlorococcus marinus subsp. pastoris str. CCMP1986 
2015-04-15 | E-GEOD-65684 | biostudies-arrayexpress
TranscriptomicsBone marrow transcriptomal differences between wild type, Fancc-deficient, Fancg-deficient, and doubly deficient (Fancc/Fancg) mice.
Seeking to challenge the current dogma that the nuclear core-complex proteins function in an entirely epistatic manner, Dr. Clapp's group developed a new double-knockout mouse nullizygous for Fancc and Fancg. Because the hematopoietic phenotype was more severe than single knockout mice, we reasone...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-22094 | biostudies-arrayexpress
UnknownEvaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model.
Not available
S-EPMC5665512 | biostudies-literature
TranscriptomicsOxymetholone therapy of Fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cycling
We used Fancd2-/- mice to understand its mechanism of action. Transcriptome analysis of cKit+ Sca1+ Lin- (KSL) cells discovered that only four genes changed their expression levels significantly after chronic OXM administration in both Fancd2−/− and wild-type mice: mKi67 and Cenpf were up-regualted ...
ORGANISM(S): Mus musculus 
2015-01-06 | E-GEOD-58724 | biostudies-arrayexpress
UnknownNormative and Maladaptive Personality Trait Models of Mood, Psychotic, and Substance Use Disorders.
Not available
S-EPMC6223804 | biostudies-literature
UnknownCabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse models.
Not available
S-EPMC9676436 | biostudies-literature
UnknownPlGF enhances TLR-dependent inflammatory responses in human mononuclear phagocytes.
Not available
S-EPMC5915625 | biostudies-literature
TranscriptomicsTranscription profiling of human bone marrow cells from normal volunteers and from children and adults with Fanconi anemia
Fanconi anemia (FA) is a rare inherited disease complicated by aplastic anemia. There is evidence that hematopoietic stem cells have lost self replicative capacity and undergo apoptosis when exposed to inhibitory cytokines including interferon gamma and tumor necrosis factor-alpha. We used gene exp...
ORGANISM(S): Homo sapiens 
2009-09-18 | E-GEOD-16334 | biostudies-arrayexpress
UnknownFirst-in-Class Phosphorylated-p68 Inhibitor RX-5902 Inhibits β-Catenin Signaling and Demonstrates Antitumor Activity in Triple-Negative Breast Cancer.
Not available
S-EPMC6825586 | biostudies-literature
UnknownFocus on ROS1-Positive Non-Small Cell Lung Cancer (NSCLC): Crizotinib, Resistance Mechanisms and the Newer Generation of Targeted Therapies.
Not available
S-EPMC7694780 | biostudies-literature
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