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ProteomicsPptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis
Mitochondrial proteins are replete with phosphorylation; however, the origin, abundance, and functional relevance of these modifications are largely unclear. Nonetheless, mitochondria possess multiple resident phosphatases, suggesting that protein dephosphorylation may be broadly important for mitoc...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-29 | PXD012743 | Pride
Mitochondia Pptc7 Phosphoproteome 
TranscriptomicsTranscription profiling of Cockayne Syndrome human fibroblasts lacking functional CSB, a SWI/SNF-like ATPase, to determine the molecular defect in CS
Cockayne syndrome (CS) is an inherited neurodevelopmental disorder with progeroid features. Although the genes responsible for CS have been implicated in a variety of DNA repair- and transcription-related pathways, the nature of the molecular defect in CS remains mysterious. We sought to define this...
ORGANISM(S): Homo sapiens 
2007-07-03 | E-GEOD-3407 | biostudies-arrayexpress
TranscriptomicsTranscriptional effects of CSB and the CSB-PGBD3 fusion protein in CSB-null UVSS1KO cells
Cockayne syndrome is a segmental progeria most often caused by mutations in the CSB gene encoding a SWI/SNF-like ATPase required for transcription-coupled DNA repair (TCR). Over 43 Mya before marmosets diverged from humans, a piggyBac3 (PGBD3) transposable element integrated into intron 5 of the CSB...
ORGANISM(S): Homo sapiens 
2014-03-20 | E-GEOD-56049 | biostudies-arrayexpress
UnknownRanking sets of morbidities using hypergraph centrality.
Not available
S-EPMC8524321 | biostudies-literature
UnknownDetermining cardiovascular risk in patients with unattributed chest pain in UK primary care: an electronic health record study.
Not available
S-EPMC10442054 | biostudies-literature
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-12 | E-MTAB-7804 | biostudies-arrayexpress
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-09 | E-MTAB-7802 | biostudies-arrayexpress
UnknownCircadian regulation of the transcriptome in a complex polyploid crop.
Not available
S-EPMC9560141 | biostudies-literature
Transcriptomicspamknight ovine abomasum1
To address the protective mechanisms generated in animals on previous exposure to this parasite, using samples of abomasal mucosa collected pre- and post- challenge from animals of differing immune status in an experimental model of Teladorsagia circumcincta infection.
ORGANISM(S): Ovis aries 
2011-05-20 | E-TABM-1149 | biostudies-arrayexpress
Transcriptomicspamknight ovine abomasum
To address the protective mechanisms generated in animals on previous exposure to this parasite, using samples of abomasal mucosa collected pre- and post- challenge from animals of differing immune status in an experimental model of T. circumcincta infection.
ORGANISM(S): Ovis aries 
2011-05-20 | E-TABM-1150 | biostudies-arrayexpress
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