Sort   by:  
 Page size 
ProteomicsPptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis
Mitochondrial proteins are replete with phosphorylation; however, the origin, abundance, and functional relevance of these modifications are largely unclear. Nonetheless, mitochondria possess multiple resident phosphatases, suggesting that protein dephosphorylation may be broadly important for mitoc...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-29 | PXD012743 | Pride
Mitochondia Pptc7 Phosphoproteome 
ProteomicsPPTC7 integrates homeostatic and physiological signals to regulate mitophagy and mitochondrial mass
Here we report that knockout of PPTC7, a mitochondrial matrix protein, hyperactivates BNIP3/NIX-mediated mitophagy in vitro and in vivo. Biochemically, the PPTC7 precursor is trapped by BNIP3 and NIX to mitochondrial outer-membrane, where PPTC7 scaffolds the assembly of the substrate-PPTC7- SCFFBXL4...
ORGANISM(S): Homo Sapiens 
PXD042744 |
UnknownPPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.
Not available
S-EPMC10575892 | biostudies-literature
UnknownPptc7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.
Not available
S-EPMC10002655 | biostudies-literature
UnknownPPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX.
Not available
S-EPMC10849627 | biostudies-literature
UnknownDual-localized PPTC7 limits mitophagy through proximal and dynamic interactions with BNIP3 and NIX.
Not available
S-EPMC11239977 | biostudies-literature
UnknownPptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis.
Not available
S-EPMC6642090 | biostudies-literature
UnknownPPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4.
Not available
S-EPMC11316107 | biostudies-literature
UnknownUpregulation of PPTC7 in brain microvascular endothelial cell aggravates diabetic cognitive dysfunction by impairing PHB2 mediated mitochondrial function.
Not available
S-EPMC12808840 | biostudies-literature
UnknownPPTC7 acts as an essential co-factor of the SCF<sup>FBXL4</sup> ubiquitin ligase complex to restrict BNIP3/3L-dependent mitophagy.
Not available
S-EPMC11873123 | biostudies-literature
Sort   by:  
 Page size