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TranscriptomicsMll2 is required for H3K4 trimethylation on bivalent promoters in ES cells whereas Mll1 is redundant
Trimethylation of histone 3 lysine 4 (H3K4me3) at promoters of actively transcribed genes is a universal epigenetic mark and a key product of Trithorax-Group action. Here we show that Mll2, one of the six Set1/Trithorax-type H3K4 methyltransferases in mammals, is required for trimethylation of bival...
ORGANISM(S): Mus musculus 
2014-01-20 | E-GEOD-52071 | biostudies-arrayexpress
TranscriptomicsmiRNA expression during in vitro mouse T cell activation (D011.10+ CD4 T cells)
Array of global miRNA expression during an in vivo effector and anergic T cell response 250 ng RNA isolated from mouse D011.10+ CD4 T cells, activated in vivo for 5 days
ORGANISM(S): Mus musculus 
2013-01-27 | E-GEOD-36607 | biostudies-arrayexpress
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-12 | E-MTAB-7804 | biostudies-arrayexpress
TranscriptomicsInfant high grade gliomas comprise multiple subgroups characterised by novel targetable gene fusions and better survival
Methylation array profiling of infant high grade gliomas identifies an intrinsic group of tumours with epigenetic profiles distinct from gliomas in older children. These tumours are characterised by very few recurrent mutations and carry a very high frequency of fusion genes. They can be diagnosed a...
ORGANISM(S): Homo sapiens 
2019-08-09 | E-MTAB-7802 | biostudies-arrayexpress
UnknownRivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial.
Not available
S-EPMC6662613 | biostudies-literature
UnknownThe benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial.
Not available
S-EPMC3386495 | biostudies-literature
TranscriptomicsWhole genome characterisation of chemoresistant ovarian cancer [NanoString miRNA]
Patients with high-grade serous ovarian cancer (HGSC) have experienced little improvement in overall survival, and standard treatment has not advanced beyond platinum-based combination chemotherapy, during the past 30 years. To understand the drivers of clinical phenotypes better, here we use whole-...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-65819 | biostudies-arrayexpress
TranscriptomicsWhole genome characterisation of chemoresistant ovarian cancer [Illumina_450K_Methylation]
Patients with high-grade serous ovarian cancer (HGSC) have experienced little improvement in overall survival, and standard treatment has not advanced beyond platinum-based combination chemotherapy, during the past 30 years. To understand the drivers of clinical phenotypes better, here we use whole-...
ORGANISM(S): Homo sapiens 
2015-05-19 | E-GEOD-65820 | biostudies-arrayexpress
UnknownUpdate on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited.
Not available
S-EPMC3286387 | biostudies-literature
UnknownEffect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke.
Not available
S-EPMC4731690 | biostudies-literature
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