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TranscriptomicsEstrogen receptor prevents p53-dependent apoptosis in breast cancer
More than two thirds of breast cancers express the estrogen receptor (ER) and depend on estrogen for growth and survival. Therapies targeting ER function including aromatase inhibitors that block the production of estrogens and ER antagonists that alter ER transcriptional activity play a central rol...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-39870 | biostudies-arrayexpress
UnknownMoths versus Bees: Contrasts in Habitat Preferences Across Barrens of the Northeastern USA.
Not available
S-EPMC11560292 | biostudies-literature
GenomicsGenome-wide analysis of ERalpha binding sites in U2OS-ERalpha cells
ChIP followed by deep sequencing was performed with antibodies to ERalpha in U2OS-ERalpha cells treated with 17beta-estradiol. Examination of Eralpha binding sites in U2OS-Eralpha cells. Sequenced input was used as a control
ORGANISM(S): Homo sapiens 
2011-05-03 | E-GEOD-28918 | biostudies-arrayexpress
UnknownMaternal obesity is associated with alterations in the gut microbiome in toddlers.
Not available
S-EPMC4237395 | biostudies-literature
UnknownGut microbiome composition is associated with temperament during early childhood.
Not available
S-EPMC4342262 | biostudies-literature
ProteomicsKinome profiling of osteosarcoma patient-derived xenograft TT2 treated with palbociclib
Osteosarcoma (OS) is the most common primary bone cancer in adolescents, young adults (AYA), and children, with up to 25% of patients developing metastatic disease, primarily in the lungs. Despite survival rates being >70% for localized tumors, patients with metastatic OS have <30% survival due to l...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD069093 | Pride
Kinase Inhibitor Bead Pi3k Cdk4/6 Mtor 
TranscriptomicsNuclear factor kappa B activation-induced anti-apoptosis renders HER2 positive cells drug resistant and accelerates tumor growth
Breast cancers with HER2 overexpression are sensitive to drugs targeting the receptor or its kinase activity. HER2-targeting drugs are initially effective against HER2- positive breast cancer, but resistance inevitably occurs. We previously found that nuclear factor kappa B is hyper-activated in the...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-52707 | biostudies-arrayexpress
ProteomicsBONCAT enables time-resolved analysis of protein synthesis in native plant tissue
Pulsing the non-canonical amino acid azidohomoalanine into Arabidopsis thaliana seedlings enables in-gel visualization, physical enrichment, and identification of newly synthesized proteins.
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2017-07-03 | PXD005577 | JPOST Repository
ProteomicsGTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins
Mass Spectrometry data pertaining to manuscript entitled, "GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-19 | MSV000089490 | MassIVE
UnknownFetal akinesia deformation sequence syndrome associated with recessive TTN variants.
Not available
S-EPMC9928776 | biostudies-literature
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