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TranscriptomicsTranscription profiling by array of yeast desiccation stress response to dessication in a time series
Response of Saccharomyces cerevisiae strain BY4741 to desiccation
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-16 | E-MEXP-2818 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast grown in gastric or duodenal medium to identify promoters that could be used to down-regulate genes used in the release of therapeutic proteins
The use of yeast as a delivery system is an attractive option for the oral administration of therapeutic agents. We recently developed mutants of Saccharomyces cerevisiae capable of lysis upon conditional down-regulation of the expression of the cell wall genes PKC1 and SRB1. The lysis mechanism of ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-01 | E-MEXP-2127 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast grown in SD media with addition of either methionine or hydrogen peroxide
Yeast cells were grown up in SD media containing all required amino acids. Each strain set was performed in triplicate. One set had no changes, the second set had 1mM methionine supplenting the media for the duration of growth and the third set was exposed to 0.5mM hydrogen peroxide for 15 minutes p...
ORGANISM(S): Saccharomyces cerevisiae 
2007-05-01 | E-MEXP-998 | biostudies-arrayexpress
TranscriptomicsPervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae
Protein-RNA interactions are integral components of nearly every aspect of biology including regulation of gene expression, assembly of cellular architectures, and pathogenesis of human diseases. However, studies in the past few decades have only uncovered a small fraction of the vast landscape of t...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-29 | E-GEOD-43747 | biostudies-arrayexpress
TranscriptomicsSteady state +/- Gly
Cells were grown to early log phase (OD600 ~ 0.2) at 30oC in 1 liter of minimal B medium (Cherest, H., and Surdin-Kerjan, Y. (1992) Genetics 130, 51-58) with or without supplementation with 10 mM glycine and harvested. All cells were harvested by rapid centrifugation at room temperature then flash f...
ORGANISM(S): Saccharomyces cerevisiae 
2004-07-17 | E-GEOD-1553 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae reveals the Cbf1 basic helix-loop-helix transcription factor is required for the response to hydrogen peroxide stress
Cbf1 is a basic helix-loop-helix transcription factor which regulates the expression of many genes of the sulphur assimilation pathway in yeast. Gamma-glutamylcysteine synthetase (GSH1), encoding the rate-limiting enzyme in glutathione biosynthesis, is constitutively elevated in cbf1 mutants indicat...
ORGANISM(S): Saccharomyces cerevisiae 
2009-10-01 | E-MEXP-2159 | biostudies-arrayexpress
TranscriptomicsTime course of glycine addition or withdrawal
+Gly 20, 40, 80: Cells were grown to early log phase (OD600 ~ 0.2) at 30oC in 1 liter of minimal B medium (Cherest, H., and Surdin-Kerjan, Y. (1992) Genetics 130, 51-58) and t=0 time point samples were harvested (250 ml). The remainder of the medium was supplemented with 10 mM glycine incubated at 3...
ORGANISM(S): Saccharomyces cerevisiae 
2010-10-08 | E-GEOD-1554 | biostudies-arrayexpress
TranscriptomicsChemical potentiator of copper-accumulation and -toxicity: Probing iron- regulons of Saccharomyces cerevisiae
RNA-seq was used to assess mRNA transcript abundance in wild type and fra2M-NM-^T S. cerevisiae (BY4741) cells treated with 2-(6-benzyl-2-pyridyl)quinazoline (BPQ) and CuSO4. BPQ potentiates copper toxicity and in yeast, in common with other organisms, a major cause of copper toxicity is damage of i...
ORGANISM(S): Saccharomyces cerevisiae 
2014-06-04 | E-GEOD-54045 | biostudies-arrayexpress
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