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TranscriptomicsTranscription profiling of effect of Azinomycin B on cultured Saccharomyces cerevisiae cells
Stress responses to DNA damaging agents show characteristic responses. The effect of Azinomycin B upon cultured yeast cells in growth conditions appears to be significant. We used microarrays to detail the global programme of gene expression induced in the stress response to Azinomycin B. Experiment...
ORGANISM(S): Saccharomyces cerevisiae 
2007-09-21 | E-GEOD-4311 | biostudies-arrayexpress
TranscriptomicsActivation-induced cytidine deaminase induces reproducible DNA breaks at many non-Ig loci in activated B cells
After immunization or infection, activation-induced cytidine deaminase (AID) initiates diversification of immunoglobulin (Ig) genes in B cells, introducing mutations within the antigen binding V regions (somatic hypermutation, SHM) and double-strand DNA breaks (DSBs) into switch (S) regions, leading...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-24827 | biostudies-arrayexpress
ProteomicsLipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation - Fluvastatin data
Naïve B cells exit quiescence and enter a proliferative state upon activation, ultimately differentiating into antibody-secreting or memory B cells. Toll-like receptor (TLR) ligands, such as lipopolysaccharide (LPS), can serve as physiological stimuli to initiate this transition. Using quantitative ...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-18 | PXD074568 | Pride
TranscriptomicsB-myb is Essential Regulator of Hematopoietic Stem Cell and Myeloid Progenitor Cell Development
The B-myb (MYBL2) gene is a member of the MYB family of transcription factors and is involved in cell cycle regulation, DNA replication and maintenance of genomic integrity. However, its function during adult development and hematopoiesis is unknown. We show here that conditional inactivation of B-m...
ORGANISM(S): Mus musculus 
2014-02-12 | E-GEOD-53875 | biostudies-arrayexpress
ProteomicsHfq is involved in global protein expression and stress response in Bordetella pertussis
In this study, we used gel-free nanoLC-MS/MS-based proteomics to compare the protein profile of B. pertussis wild type and an isogenic hfq defective mutant strain under control an iron limited conditions. We found that Hfq affects the abundance of 302 proteins, which represents 8% of the total B. pe...
ORGANISM(S): Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2020-02-18 | PXD011753 | Pride
Proteomics Iron limitation Stress response Hfq B. pertussis 
TranscriptomicsCell cyclin kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1
Sle2c1 is an NZM2410-derived lupus susceptibility locus that induces an expansion of the B1a cell compartment. B1a cells have a repertoire enriched for autoreactivity, and an expansion of this B cell subset occurs in several mouse models of lupus. Here we showed that expression of Sle2c1 enhances NZ...
ORGANISM(S): Mus musculus 
2010-07-24 | E-GEOD-23114 | biostudies-arrayexpress
UnknownThe complete mitochondrial genome of Paracolopha morrisoni (Baker, 1919) (Hemiptera: Aphididae).
Not available
S-EPMC7706891 | biostudies-literature
ProteomicsSystems-level phosphoproteomic and RPPA profiling reveals stress and DNA damage signalling as early drivers of polymyxin B neurotoxicity
Polymyxins remain indispensable last-line antibiotics for multidrug-resistant Gram-negative infections, yet their clinical use in central nervous system (CNS) infections is constrained by poorly understood neurotoxicity. Here, we define the early molecular signalling events underlying polymyxin B-in...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-14 | PXD075314 | Pride
Polymyxin b  neurotoxicity  central nervous system  phosphoproteomics  reverse phase protein array  apoptosis  dna damage signalling  antibiotic toxicodynamics. 
TranscriptomicsThe dura mater acts as an autonomous B cell niche supporting immune responses during chronic Trypanosoma brucei infection
The dura mater hosts a rich population of B cell progenitors, yet its capacity to sustain B cell development during systemic lymphopenia remains unclear. Using Trypanosoma brucei infection, which induces peripheral B cell depletion, we demonstrate that the murine dura mater maintains intact B cell l...
ORGANISM(S): Mus musculus 
2026-02-04 | E-MTAB-16521 | biostudies-arrayexpress
TranscriptomicsTranscrioptome analysis of human primary macrophages stimulated by bacterial endotoxin lipopolysaccharide (LPS), and (1,3)-b-glucans, curdlan and glucan from baker´s yeast (GBY)
We performed gene expression microarray experiments to compare the global transcriptional response induced by b-glucans and LPS with their secretomes. We identified 1683, 767 and 1447 genes with over two-fold increase or decrease in LPS-, curdlan- or GBY-stimulated macrophages, respectively. We show...
ORGANISM(S): Homo sapiens 
2014-05-15 | GSE32282 | GEO
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