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TranscriptomicsThe transient inactivation of the master cell cycle phosphatase Cdc14 causes genomic instability in diploid cells of Saccharomyces cerevisiae.
Genomic instability is a common feature found in cancer cells. Accordingly, many tumor suppressor genes identified in familiar cancer syndromes are involved in the maintenance of the stability of the genome during every cell division, and are commonly referred to as caretakers. Inactivating mutation...
ORGANISM(S): Saccharomyces cerevisiae 
2015-05-05 | E-GEOD-68530 | biostudies-arrayexpress
UnknownValuing improvements in the ecological integrity of local and regional waters using the biological condition gradient.
Not available
S-EPMC10160978 | biostudies-literature
MetabolomicsFunctional analysis of isoprenoid precursors biosynthesis by quantitative metabolomics and isotopologue profiling

INTRODUCTION: Isoprenoids are amongst the most abundant and diverse biological molecules and are involved in a broad range of biological functions. Functional understanding of their biosynthesis is thus key in many fundamental and applicative fields, including systems biology, me...

2021-04-01 | MTBLS923 | MetaboLights
UnknownBiallelic MADD variants cause a phenotypic spectrum ranging from developmental delay to a multisystem disorder.
Not available
S-EPMC7447524 | biostudies-literature
ProteomicsMitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced life-span
Changes in the rate and fidelity of mitochondrial protein synthesis impact the metabolic and physiological roles of mitochondria. Here we explored how environmental stress in the form of a high-fat diet modulates mitochondrial translation using mutant mice with error-prone (Mrps12ep/ep) or hyper-acc...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024633 | Pride
Mitochondria Mouse Heart 
ProteomicsPMS2 inhibitor NP1867 cysteinome adduction by cell-based proteomincs
MMR protein PMS2 is a druggable target. Discovery and characterisation of first-in-class small molecule MMR pathway modulator NP1867.
ORGANISM(S): Homo sapiens (Human) 
2026-04-28 | PXD077673 | Pride
UnknownCabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma.
Not available
S-EPMC5024539 | biostudies-literature
UnknownMitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan.
Not available
S-EPMC8282274 | biostudies-literature
MetabolomicsSimultaneously discovering the fate and biochemical effects of pharmaceuticals through untargeted metabolomics
Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provides an opportunity to simultaneously gain deep insights int...
2023-07-03 | MTBLS2746 | MetaboLights
UnknownGenome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion.
Not available
S-EPMC2644145 | biostudies-literature
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