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MetabolomicsSPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids
Characterization of endogenous metabolites and xenobiotics is essential to deconvoluting the genetic and environmental causes of disease. However, surveillance of chemical exposure and disease-related changes in large cohorts requires an analytical platform that offers rapid measurement, high sensit...
2017-02-14 | MTBLS427 | MetaboLights
ProteomicsMulti-Omic Evidence of Brain Region Specific APOE Genotype Perturbations in Alzheimer's Disease
Simultaneous extraction of proteins and lipids from human frontal cortex and cerebellum brain tissue was performed using the MPLEx procedure for both control and Alzheimer's disease patients. The isolated proteins were then reduced, alkylated, tryptically digested and evaluated with LC-IMS-MS. The p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-08 | MSV000092627 | MassIVE
MetabolomicsGNPS - Multi-Omic Evidence of Brain Region Specific APOE Genotype Perturbations in Alzheimer's Disease
Simultaneous extraction of proteins and lipids from human frontal cortex and cerebellum brain tissue was performed using the MPLEx procedure for both control and Alzheimer's disease patients. The isolated proteins were then reduced, alkylated, tryptically digested and evaluated with LC-IMS-MS. The p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-08 | MSV000092627 | GNPS
ProteomicsMolecular Signatures of Preeclampsia and Gestational Diabetes Mellitus Utilizing Multi-Omics Analyses, Part 2
The application of multi-omic evaluations, multi-dimensional analysis methods, and new cheminformatics-based visualization tools to provide an in depth understanding of the molecular changes taking place in preeclampsia (PRE) and gestational diabetes mellitus (GDM) patients. Since PRE and GDM are tw...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-02 | MSV000085361 | MassIVE
ProteomicsMolecular Signatures of Preeclampsia and Gestational Diabetes Mellitus Utilizing Multi-Omics Analyses, Part 1
The application of multi-omic evaluations, multi-dimensional analysis methods, and new cheminformatics-based visualization tools to provide an in depth understanding of the molecular changes taking place in preeclampsia (PRE) and gestational diabetes mellitus (GDM) patients. Since PRE and GDM are tw...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-01 | MSV000085357 | MassIVE
MetabolomicsGNPS - Molecular Signatures of Preeclampsia and Gestational Diabetes Mellitus Utilizing Multi-Omics Analyses, Part 1
The application of multi-omic evaluations, multi-dimensional analysis methods, and new cheminformatics-based visualization tools to provide an in depth understanding of the molecular changes taking place in preeclampsia (PRE) and gestational diabetes mellitus (GDM) patients. Since PRE and GDM are tw...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-01 | MSV000085357 | GNPS
ProteomicsProteomic assessment of serum biomarkers of longevity in older men
We utilized a high throughput discovery-based proteomics platform to identify serum peptides and proteins that were associated with the attainment of longevity in a longitudinal study of community-dwelling men age 65 years or older. Baseline serum in 1196 men were analyzed using liquid chromatograph...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-06-19 | MSV000085611 | MassIVE
ProteomicsAutomating Multidimensional Liquid Chromatography, Ion Mobility Spectrometry and Mass Spectrometry Data Analyses Using Skyline
Recent advances in ion mobility spectrometry (IMS) have illustrated its power in the structural characteristics of a molecule, especially when coupled with other separations dimensions such as liquid chromatography (LC) and mass spectrometry (MS). However, these three separation techniques together ...
ORGANISM(S): Bos Taurus Saccharomyces Cerevisiae 
PXD010650 | panorama
ProteomicsAAV Orbitrap CD-MS for AAV2, AAV6, and AAV8
CD-MS analysis collected on an Orbitrap UHMR. Note, this data was collected on a beta version of the DMT software and thus contains STORI files stored in separate zip files. The DMT files are also included as supplemental files, along with the UniDecCD processing parameters.
ORGANISM(S): Adeno-associated Dependoparvovirus A (ncbitaxon:1511891) 
2023-04-05 | MSV000091650 | MassIVE
ProteomicsFrom plants to ants: Evaluating lipidomic changes in leaf-cutter ant fungus gardens
Leaf-cutter ants use fresh plant material to cultivate an obligate mutualistic fungus Leucoagaricus gongylophorus in specialized fungus gardens to access and transform nutrients from plant biomass that would otherwise be unavailable to the ants. Here, we evaluated the lipidomic differences between t...
ORGANISM(S): Environmental Samples <bacteria> (ncbitaxon:48479) 
2019-10-30 | MSV000084520 | MassIVE
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