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TranscriptomicsSpecies-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts
Most eukaryotic genes express mRNAs with alternative polyadenylation sites at their 3’ ends. Here we show that polyadenylated 3’ termini in three yeast species (S. cerevisiae, K. lactis, D. hansenii) are remarkably heterogeneous. Instead of a few discrete 3’ ends, the average yeast gene has an “en...
ORGANISM(S): Saccharomyces cerevisiae 
2013-07-03 | E-GEOD-47661 | biostudies-arrayexpress
Unknown"Cognitive, emotion control, and motor performance of adolescents in the NCANDA study: Contributions from alcohol consumption, age, sex, ethnicity, and family history of addiction": Correction to Sullivan et al. (2016).
Not available
S-EPMC7405886 | biostudies-literature
TranscriptomicsIdentification of a complex genetic network involved in Saccharomyces cerevisiae colony morphology
When grown on solid substrates, different microorganisms often form colonies with very specific morphologies. Whereas the pioneers of microbiology often used colony morphology to discriminate between species and strains, the phenomenon has not received much recent attention. In this study, we use ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-27 | E-GEOD-36151 | biostudies-arrayexpress
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
UnknownA novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change of C-reactive protein
Not available
S-SCDT-10_15252-EMMM_202216236 | biostudies-other
TranscriptomicsLife cycle of Drosophila melanogaster
Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germli...
ORGANISM(S): Drosophila melanogaster 
2003-01-05 | E-GEOD-94 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of murine livers after resveratrol treatment of mice on a high-calorie diet
Resveratrol (3,5,4'-trihydroxystilbene) extends the lifespan of diverse species including yeast, worms, and flies. In these organisms, lifespan extension is dependent on Sir2, a conserved deacetylase proposed to underlie the beneficial effects of caloric restriction (CR). Here we show that resveratr...
ORGANISM(S): Mus musculus 
2008-06-21 | E-GEOD-6089 | biostudies-arrayexpress
GenomicsGenome-wide maps of nucleosome positions in Saccharomyces strains bearing heterologous DNA on yeast artificial chromosomes
We identify the cis and trans determinants of nucleosome positioning using a functional evolutionary approach involving S. cerevisiae strains containing large genomic regions from other yeast species. In a foreign species, nucleosome depletion at promoters is maintained over poly(dA:dT) tracts, wher...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-30 | E-GEOD-39011 | biostudies-arrayexpress
UnknownIncidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study.
Not available
S-EPMC6105576 | biostudies-literature
GenomicsPerturbation of mRNP biogenesis reveals a dynamic landscape of the Rrp6-dependent surveillance machinery trafficking along the yeast genome (ChIP-seq dataset)
In order to dissect the nuclear RNA quality control (QC) mechanisms, we used a powerful assay based on global perturbation of mRNP biogenesis in yeast Saccharomyces cerevisiae by the bacterial Rho helicase. We have monitored the global RNA levels upon Rho activation and compare it to basal RNA level...
ORGANISM(S): Saccharomyces cerevisiae 
2019-12-04 | E-MTAB-7539 | biostudies-arrayexpress
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