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TranscriptomicsRNA-Seq of anterior cruciate ligament and knee joint synovium in dogs that are affected with cruciate rupture compared to matched controls.
The intent of the experiment was to identify genes that were differentially expressed between dogs affected with anterior cruciate ligament (ACL) rupture and breed-matched controls. Anterior cruciate ligament and knee synovial tissue biopsies were collected from 4 ACL rupture affected cases and 4 un...
ORGANISM(S): Canis lupus familiaris 
2021-02-26 | E-MTAB-10119 | biostudies-arrayexpress
TranscriptomicsEccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways
Full title: Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. Unaccustomed eccentric exercise damages muscle tissue stimulating mechanisms of recovery and remodeling that may be affected by cellular protection by the sex...
ORGANISM(S): Homo sapiens 
2009-12-16 | E-GEOD-19062 | biostudies-arrayexpress
TranscriptomicsGene expression arrays comparing Kluyveromyces lactis wild-type a cells to MATa2 knock-out a cells and wild-type alpha cells to MATalpha2 knock-out alpha cells
We examine how different transcriptional network structures can evolve from a common, ancestral network. We show that regulatory protein modularity, conversion of one cis-regulatory sequence to another, distribution of binding energy among protein-protein and protein-DNA interactions, and exploitati...
ORGANISM(S): Kluyveromyces lactis 
2012-06-29 | E-GEOD-39027 | biostudies-arrayexpress
GenomicsKDM5 Lysine Demethylases Are Involved in Maintenance of 3'UTR Length [ChIP-Seq]
We discovered that the Saccharomyces cerevisiae lysine demethylase, Jhd2 (also known as KDM5), recruits 3'UTR processing machinery and promotes alteration of 3'UTR length in a demethylase-dependent manner. Interaction of Jhd2 with both chromatin and RNA suggests that Jhd2 affects selection of polyad...
ORGANISM(S): Saccharomyces cerevisiae 
2016-03-23 | E-GEOD-67211 | biostudies-arrayexpress
TranscriptomicsVerification of a custom chip which measures abundance, isoforms and alleles in Drosophila
Analysis of differential expression using the 3’ expression module revealed 34% probe sets showed evidence for a sex bias and alternative exon sex bias was identified for 164 genes. Intriguingly, allelic imbalance was detected for 37% of 6,579 probe sets examined which contained heterozygous SNP lo...
ORGANISM(S): Drosophila simulans 
2011-09-12 | E-GEOD-31750 | biostudies-arrayexpress
TranscriptomicsKDM5 Lysine Demethylases Are Involved in Maintenance of 3'UTR Length [RNA-Seq]
We discovered that the Saccharomyces cerevisiae lysine demethylase, Jhd2 (also known as KDM5), recruits 3'UTR processing machinery and promotes alteration of 3'UTR length in a demethylase-dependent manner. Interaction of Jhd2 with both chromatin and RNA suggests that Jhd2 affects selection of polyad...
ORGANISM(S): Saccharomyces cerevisiae 
2016-03-23 | E-GEOD-67163 | biostudies-arrayexpress
UnknownOutcomes Following Vascular and Endovascular Procedures Performed During the First COVID-19 Pandemic Wave.
Not available
S-EPMC11462031 | biostudies-literature
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