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The Saccharomyces cerevisiae transcription factor Aft1 is activated in iron-deficient cells to induce the expression of iron regulon genes, which coordinate the increase of iron uptake and remodel cellular metabolism to survive low iron conditions. In addition, Aft1 has been implicated in numerou...
ORGANISM(S): Saccharomyces cerevisiae 
Deletion mutants of all established glucose signalling and some metabolic pathway members have been analyzed by expression profiling. Tps2 double mutants are profiled to verify the prediction that Tps2 is one of the most downstream transcriptional components.
ORGANISM(S): Saccharomyces cerevisiae 
Non-essential knockouts of chromatin modifiers have been investigated by expression profiling.
ORGANISM(S): Saccharomyces cerevisiae 

This study includes samples from two projects: Collaborative Genetic Study of Nicotine Dependence (COGEND; PI: Laura Bierut) and University of Wisconsin Transdisciplinary Tobacco Use Research Center (UW-TTURC; PI: Timothy Baker).

Data are available for an additional 1420 COGEND subjects th...

Identification of somatic alterations in cancer has become feasible with the massive adoption of next generation sequencing. However, due to variability in sequencing and informatics pipelines, a common somatic reference is needed. We thus performed paired whole genome sequencing of a metastatic mel...
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