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Proteomicsquantitative crosslinking of ADP treated mitochondria isolated from HEK293 cells
Acute treatment of isolated mitochondria with 1.5 mM ADP. Crosslinking and quantitative comparison to non-treated control using iqPIR technology for quantitative crosslinking.
ORGANISM(S): Homo sapiens (Human) 
2022-07-29 | PXD031644 | Pride
Hek293 Qxl-ms Mitochondria 
ProteomicsAge induced interactome remodeling in muscle mitochondria
A novel quantitative crosslinking mass spectrometry technique (qXL-MS) was applied to elucidate interactome changes in aged murine skeletal muscle mitochondria that contribute to age-related mitochondrial functional decline. Reported here are results from initial investigations of murine muscle mit...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD031643 | Pride
Proteomics Protein interactions Murine muscle Mitochondria Xl-ms 
ProteomicsInteractome quantitation reveals non-energetic mitochondrial roles in cell type specialization in murine kidney
Evolution of multicellular life forms has involved adaptation of organs that consist of multiple cell types, each with unique functional properties that as a collection, achieve complex organ function. Since each cell type is adapted to deliver specific functionality within the context of an organ,...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD062841 | Pride
Mouse Kidney Xl-ms Mitochondria 
ProteomicsInteractome quantitation reveals non-energetic mitochondrial roles in cell type specialization in murine kidney
Evolution of multicellular life forms has involved adaptation of organs that consist of multiple cell types, each with unique functional properties that as a collection, achieve complex organ function. Since each cell type is adapted to deliver specific functionality within the context of an organ,...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD062836 | Pride
Dia Mouse Kidney Xl-ms Mitochondria 
ProteomicsInteractome quantitation reveals non-energetic mitochondrial roles in cell type specialization in murine kidney
Evolution of multicellular life forms has involved adaptation of organs that consist of multiple cell types, each with unique functional properties that as a collection, achieve complex organ function. Since each cell type is adapted to deliver specific functionality within the context of an organ,...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD062838 | Pride
Dia Mouse Kidney Xl-ms Mitochondria 
ProteomicsMitochondrial interactome quantitation reveals structural changes in metabolic machinery in the failing murine heart
Advancements in cross-linking mass spectrometry (XL-MS) for structural analysis of proteins bridge the gap between purified systems and native tissue environments. Here, isobaric quantitative protein interaction reporter technology (iqPIR) was utilized to further extend XL-MS to the first system-wid...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-27 | PXD035712 | Pride
Quantitative cross-linking  heart failure  cardiac hypertrophy  mitochondria  protein interactions  interactome  mass spectrometry  systems structural biology 
ProteomicsCombining quantitative proteomics and interactomics for a deeper insight into molecular differences between human cell lines
Cellular functional pathways have evolved through selection based on fitness benefits conferred through protein intra- and inter-molecular interactions that comprise all protein conformational features and protein-protein interactions, collectively referred to as the interactome. While the interact...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-17 | PXD055943 | Pride
Mouse Cross-linking Mitochondria 
ProteomicsCombining quantitative proteomics and interactomics for a deeper insight into molecular differences between human cell lines
Cellular functional pathways have evolved through selection based on fitness benefits conferred through protein intra- and inter-molecular interactions that comprise all protein conformational features and protein-protein interactions, collectively referred to as the interactome. While the interact...
ORGANISM(S): Homo sapiens (Human) 
2024-09-16 | PXD052801 | Pride
Dia Human Cell line 
ProteomicsParacrine Signaling in Visceral Fat
Accumulation of visceral (VIS) as opposed to subcutaneous (SUB) fat is a predictor of metabolic disorders, insulin resistance, and cardiovascular disease. This is due in part to the limited capacity of VIS fat to buffer lipids allowing them to deposit in insulin-sensitive tissues, thus impairing ins...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD014672 | Pride
Paracrine signaling Mouse Visceral fat 
ProteomicsThe long noncoding RNA Caren protects against heart failure via suppressing the Hint1-ATM signaling pathway
Long noncoding RNAs (lncRNAs) have potential as novel therapeutic targets in cardiac disease, but their function in heart failure (HF) is not yet fully understood. Using a gene trapping approach in mouse embryonic stem cells, we identified a novel cytoplasmic lncRNA, dubbed Caren (cardiomyocyte-enri...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-08 | PXD016186 | Pride
Mouse Heart failure Lncrna 
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