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TranscriptomicsChromatin immunoprecipitation of mouse embryonic stem cells, mesenchymal/neuronal progenitors and hepatocytes to identify epigenetic control of HOX gene termporal regulation
To reveal changes in chromatin state and correlate with transcriptional activity during embryonic development
ORGANISM(S): Mus musculus 
2009-06-05 | E-TABM-677 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse hematopoietic stem cells and other stages of the hematopoietic hierarchy, and to identify the shared expressed genes among the hematopoietic cells and neural and embryonic stem cells in mouse
Study to determine global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy, and to identify the shared expressed genes among the hematopoietic cells and neural and embryonic stem cells in mouse.
ORGANISM(S): Mus musculus 
2007-07-19 | E-CBIL-33 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human osteosarcoma U2OS cell line conditionally expressing HA-tagged PRDM5
PRDM5 is a recently identified member of the PRDM family of proteins, which functions as a transcriptional repressor by recruiting histone methyltransferase G9A to DNA, and behaves as a putative tumor suppressor in different types of cancer. We investigated PRDM5 function by identifying its target g...
ORGANISM(S): Homo sapiens 
2009-01-31 | E-GEOD-10580 | biostudies-arrayexpress
TranscriptomicsIn depth analysis of the interaction of HIV 1 with cellular microRNA biogenesis and effector mechanisms
The question of how HIV 1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4+ PBMCs and...
ORGANISM(S): Homo sapiens 
2014-07-31 | E-GEOD-59944 | biostudies-arrayexpress
TranscriptomicsIdentification of DNA palindromes in the MCF-7 breast cancer cell line
DNA palindromes are implicated as a causative agent in cancer formation due to their association with genomic instability and DNA amplification. However, the unique properties of palindromes render them refractory to current methods of analyses including PCR amplification and cloning into bacterial ...
ORGANISM(S): Homo sapiens 
2013-01-25 | E-GEOD-43679 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse HOXB4 in adult hematopoietic stem and progenitor cells with inducible HOXB4 to identify its target genes
HOXB4 mediates expansion of adult and embryo-derived hematopoietic stem cells (HSCs) when expressed ectopically. To define the underlying molecular mechanisms, we performed gene expression profiling in combination with subsequent functional analysis using enriched adult HSCs expressing inducible HO...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9010 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of blasts from three APL patients expressing PML/RAR before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours
Gene expression profiles in blasts from three APL patients expressing PML/RAR were assessed before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours. We then studied a U937 clone conditionally expressing PML/RAR (U937-PR), (Grignani et al. 1993) (Alcalay et al. 2003), and comp...
ORGANISM(S): Homo sapiens 
2004-12-31 | E-MEXP-149 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryoid bodies with HOXB4 induced or not induced to identify its target genes
To unravel the molecular mechanism by which HOXB4 promotes the expansion of early hematopoietic progenitors within differentiating ES cells, we analzed the gene expression profiles of embryoid bodies (EBs) in which transcription of HOXB4 had been induced or not induced. A substantial number of the i...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9044 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of Plasmodium falciparum strains to identify gene copy number variation throughout the genome
Not available
ORGANISM(S): Plasmodium falciparum 
2009-11-19 | E-TABM-589 | biostudies-arrayexpress
TranscriptomicsMicroRNAs differentially present in the plasma of HIV elite controllers
Elite controllers maintain HIV-1 viral loads below the limit of detection. The mechanisms responsible for this phenomenon are poorly understood. As microRNAs (miRNAs) are regulators of gene expression and some of them modulate HIV infection, we have studied the miRNA profile in plasma from HIV elite...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-58868 | biostudies-arrayexpress
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