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TranscriptomicsHNF1-alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP1 & ChREBP activation
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1a (HNF1a), were identified in 50% of hepatocellular adenomas (HCA) phenotypically characterized by a striking steatosis. To understand the molecular basis of this aberrant lipid storage, w...
ORGANISM(S): Homo sapiens 
2007-05-01 | E-GEOD-7473 | biostudies-arrayexpress
TranscriptomicsFrequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Inflammatory hepatocellular adenomas (IHCA) are benign liver tumours defined by the presence of inflammatory infiltrates and by the elevated expression of inflammatory proteins in tumour hepatocytes1,2. Here we show a striking activation of the IL6 signalling pathway in this tumour type, and sequenc...
ORGANISM(S): Homo sapiens 
2008-12-24 | E-GEOD-11819 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 57 hepato cellular carcinoma tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools
A ""Cartes d'Identite des Tumeurs"" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). 65 samples on Affymetrix HG-U133A GeneChips arrays (57 tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools). Identification of six subgroups of Hepatocellular...
ORGANISM(S): Homo sapiens 
2007-03-26 | E-TABM-36 | biostudies-arrayexpress
GenomicsRNA-sequençing of 21 inflammatory hepatocellular adenomas
The French ICGC project on liver tumors is coordinated by Pr Jessica Zucman-Rossi and funded by Inca (French Institute for Cancer). The aim of the present project is to identify the catalog of somatic and germline mutations in liver tumors.The present series corresponds to 21 RNA-seq of IHCA samples...
EGAS00001003685 | EGA
GenomicsWhole Exome Sequencing of 15 Tumor/Normal pairs of inflammatory hepatocellular adenomas
The French ICGC project on liver tumors is coordinated by Pr Jessica Zucman-Rossi and funded by Inca (French Institute for Cancer). The aim of the present project is to identify the catalog of somatic and germline mutations in liver tumors. The present series corresponds to 15 Tumor/Normal pairs of ...
EGAS00001003686 | EGA
GenomicsEGAS00001003685 - samples
Description not provided
EGAD00001005284 | EGA
GenomicsEGAS00001003686 - samples
Description not provided
EGAD00001005283 | EGA
GenomicsFunGeST - Functional Genomics from cancer research to personalized medicine
Data Access Committee EGAC00001002924
EGAC00001002924 | EGA
GenomicsExome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
Genomic analyses promise to improve tumor characterization in order to optimize personalized treatment for patients with hepatocellular carcinoma (HCC). Exome sequencing analysis of 243 liver tumors revealed mutational signatures associated with specific risk factors, mainly combined alcohol/tobacco...
EGAS00001001002 | EGA
GenomicsIntegrative genomic profiling of hepatocellular adenomas reveals recurrent FRK activating mutations and mutational processes of malignant transformation
Hepatocellular adenomas (HCA) are benign liver tumors predominantly developed in women using oral contraception. Here, exome sequencing identified novel recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation and cell proliferation sensitive to Src inhibitors. We a...
EGAS00001000679 | EGA
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