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MetabolomicsSeipin Governs Caveolin-1 Trafficking Through Modulating Sphingolipid-Glycerolipid Balance

Dysregulation of Caveolin-1 (CAV1), a key component of caveolae, leads to pleiotropic disorders; yet, the mechanisms controlling its trafficking remain unclear. Here, we show that the lipid droplet (LD) biogenesis factor seipin controls CAV1 localization. Seipin deficiency in mice and HeLa cells ...

2025-07-22 | MTBLS12759 | MetaboLights
MetabolomicsIonic homeostasis, carbohydrate metabolism, and oxidative balance underlie wild soybean resistance to low potassium stress

The scarcity of potassium resources in farmland soils poses a major challenge to global food security. Wild soybean (Glycine soja), a valuable wild germplasm related to cultivated soybeans, is known for its high-stress resistance and adaptability. This study comprehensively compares two wild soyb...

2026-04-12 | MTBLS14256 | MetaboLights
MetabolomicsIonic homeostasis, carbohydrate metabolism, and oxidative balance underlie wild soybean resistance to low potassium stress

The scarcity of potassium resources in farmland soils poses a major challenge to global food security. Wild soybean (Glycine soja), a valuable wild germplasm related to cultivated soybeans, is known for its high-stress resistance and adaptability. This study comprehensively compares two wild soyb...

2025-07-22 | MTBLS12462 | MetaboLights
MetabolomicsFisetin ameliorates acute colitis in mice via gut microbiota associated linoleic acid metabolism to regulate Th17/Treg balance

This study investigated the therapeutic effects of FST on colitis in mice by exploring its impact on the gut microbiota, metabolites, and immune response. The results show FST alleviated colitis in mice, including mitigated weight loss, improved colon length shortening, and reduced mRNA expressi...

2025-12-03 | MTBLS13284 | MetaboLights
MetabolomicsBlocking NKp46-CCR6-ILC3 autophagy alleviates necrotizing enterocolitis by restoring energy metabolism balance

Group 3 innate lymphoid cells (ILC3s) play a crucial role in intestinal inflammatory disorders such as necrotizing enterocolitis (NEC) in neonates; however, the mechanisms by which ILC3s contribute to NEC remain unclear. In this study, single-cell transcriptomics, in vivo experiments on T cell-de...

2026-04-12 | MTBLS12891 | MetaboLights
MetabolomicsGut Microbiota-Mediated Tryptophan Metabolism Plays Dual Effects in Diffuse Large B-Cell Lymphoma via Regulating 3-IAA/5-HTP Balance and Antitumor Immunity
Timing-dependent tryptophan diets differentially modulate DLBCL outcomes via microbiota-derived 3-IAA (pre-inoculation, anti-tumor) versus 5-HTP (post-inoculation, pro-tumor), with pectin restoring microbial balance to enable a timed tryptophan-pectin precision nutrition strategy for enhanced immuno...
2026-09-07 | MTBLS15570 | MetaboLights
MetabolomicsDisruption of Redox Balance Enhances the Effects of BRAF-inhibitors in Melanoma
Not available
ORGANISM(S): Homo sapiens 
ST001339 | MetabolomicsWorkbench
MetabolomicsApplication of the redox metabolite detection method for profiling redox state following pharmacologic perturbations of redox balance in cells (part III)
Not available
ORGANISM(S): Homo sapiens 
ST001771 | MetabolomicsWorkbench
MetabolomicsApplication of the redox metabolite detection method for profiling redox state following pharmacologic perturbations of redox balance in cells (part II)
Not available
ORGANISM(S): Homo sapiens 
ST001770 | MetabolomicsWorkbench
MetabolomicsApplication of the redox metabolite detection method for profiling redox state following pharmacologic perturbations of redox balance in cells (part I)
Not available
ORGANISM(S): Homo sapiens 
ST001769 | MetabolomicsWorkbench
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