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UnknownPyrimidine Nucleotides Containing a (S)-Methanocarba Ring as P2Y6 Receptor Agonists.
Both agonists and antagonists of the UDP-activated P2Y6 receptor (P2Y6R) have been proposed for therapeutic use, in conditions such as cancer, inflammation, neurodegeneration and diabetes. Uracil nucleotides containing a South-bicyclo[3.1.0]hexane ((S)-methanocarba) ring system in place of the ribos...
S-EPMC5798474 | biostudies-literature
UnknownDerivation, Functionalization of (S)-Goniothalamin from Goniothalamus wightii and Their Derivative Targets SARS-CoV-2 MPro, SPro, and RdRp: A Pharmacological Perspective.
The tracing of an alternative drug, Phytochemicals is a promising approach to the viral threats that have emerged over the past two years. Across the world, herbal medicine is a better solution against anti-viral diseases during pandemic periods. Goniothalamus wightii is an herbal plant, whic...
S-EPMC9612040 | biostudies-literature
UnknownIr6In32S21, a polar, metal-rich semiconducting subchalcogenide.
Subchalcogenides are uncommon, and their chemical bonding results from an interplay between metal-metal and metal-chalcogenide interactions. Herein, we present Ir6In32S21, a novel semiconducting subchalcogenide compound that crystallizes in a new structure type in th...
S-EPMC8146499 | biostudies-literature
UnknownROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.
Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of inflammasome activation and was previously shown to form large transmembrane pores after cleavage by inflammatory caspases to generate the GSDMD N-terminal domain (GSDMD-NT)1-10. Here we report ...
S-EPMC11283288 | biostudies-literature
UnknownPyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.
The P2Y(6) receptor is a cytoprotective G-protein-coupled receptor (GPCR) activated by UDP (EC(50) = 0.30 microM). We compared and combined modifications to enhance P2Y(6) receptor agonist selectivity, including ribose ring constraint, 5-iodo and 4-alkyloxyimino modifications, and phosphate modifica...
S-EPMC2935147 | biostudies-literature
UnknownOptimized Prediction Models from Fundus Imaging and Genetics for Late Age-Related Macular Degeneration.
Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. In this study, we compare the performance of retinal fundus images and genetic-information-based machine learning models for the prediction of late AMD. Using data from the Age-related Eye Disease Study, w...
S-EPMC8617775 | biostudies-literature
UnknownSeroprevalence of Strongyloides stercoralis infection in a South Indian adult population.

Background

The prevalence of Strongyloides stercoralis infection is estimated to be 30-100 million worldwide, although this an underestimate. Most cases remain undiagnosed due to the asymptomatic nature of the infection. We wanted to estimate the seroprevalence of S. stercoralis infection in...
S-EPMC9299326 | biostudies-literature
UnknownStaphylococcus aureus Coordinates Leukocidin Expression and Pathogenesis by Sensing Metabolic Fluxes via RpiRc.
Staphylococcus aureus is a formidable human pathogen that uses secreted cytolytic factors to injure immune cells and promote infection of its host. Of these proteins, the bicomponent family of pore-forming leukocidins play critical roles in S. aureus pathogenesis. The regulatory mechanisms governing...
S-EPMC4916384 | biostudies-literature
UnknownMarine Sponge-Derived Streptomyces sp. SBT343 Extract Inhibits Staphylococcal Biofilm Formation.
Staphylococcus epidermidis and Staphylococcus aureus are opportunistic pathogens that cause nosocomial and chronic biofilm-associated infections. Indwelling medical devices and contact lenses are ideal ecological niches for formation of staphylococcal biofilms. Bacteria within biofilms...
S-EPMC5311426 | biostudies-literature
Unknown4-Sulfamoylanilinium nitrate.
In the crystal structure of the title compound, C(6)H(9)N(2)O(2)S(+)·NO(3) (-), the cations and anions are connected by N-H⋯O hydrogen bonds into a three-dimensional network.
S-EPMC3201237 | biostudies-literature
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