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UnknownCD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia.
Not available
S-EPMC4876311 | biostudies-literature
TranscriptomicsAssessment of MEK-ERK pathway targeting by BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias [Patient samples]
Multiple myeloma (MM) is a malignant disorder characterized by the clonal proliferation of plasma cells (PCs) in the bone marrow (BM). The genetic background and clinical course of the disease are largely heterogeneous, and MM pathophysiology ranges from the premalignant condition of monoclonal gamm...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-66291 | biostudies-arrayexpress
TranscriptomicsAssessment of MEK-ERK pathway targeting by BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias [U266 human myeloma cell line]
Multiple myeloma (MM) is a malignant disorder characterized by the clonal proliferation of plasma cells (PCs) in the bone marrow (BM). The genetic background and clinical course of the disease are largely heterogeneous, and MM pathophysiology ranges from the premalignant condition of monoclonal gamm...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-66292 | biostudies-arrayexpress
TranscriptomicsAssessment of MEK-ERK pathway targeting by BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-66293 | biostudies-arrayexpress
UnknownCytidine deaminase enzymatic activity is a prognostic biomarker in gemcitabine/platinum-treated advanced non-small-cell lung cancer: a prospective validation study.
Not available
S-EPMC6265283 | biostudies-literature
TranscriptomicsTranscription profiling of human multiple myelome samples reveals up-regulation of translational machinery and distinct genetic subgroups characterize hyperdiploidy
Karyotypic instability, including numerical and structural chromosomal aberrations, represents a distinct feature of multiple myeloma (MM). 40-50% of patients displayed hyperdiploidy, defined by recurrent trisomies of non-random chromosomes. To characterize hyperdiploid (H) and nonhyperdiploid (NH) ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6401 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human multiple myeloma patients classified using the TC system to provide a molecular characterization of the TC groups
PURPOSE. The deregulation of CCND1, CCND2 and CCND3 genes represents a common event in multiple myeloma (MM). The recently proposed TC classification grouped MM patients into five classes on the basis of their cyclins D expression profiles and the presence of the main translocations involving the im...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2912 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human purified plasma cells (PCs) obtained from 90 newly diagnosed multiple myeloma (MM) reveals a distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma
Background and objective: The chromosome 13 deletion (del(13)) represents one of the most frequent chromosomal alterations in multiple myeloma (MM). del(13) is associated with an unfavorable prognosis, although there is an increasing agreement that its prognostic relevance has to be related to the p...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6365 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human plasma cells from patients with monoclonal gammopathy of undetermined significance, multiple myeloma or plasma-cell leukaemia
This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 7 monoclonal gammopathy of undetermined significance (MGUS), 39 newly diagnosed multiple myeloma (MM) and 6 plasma-cell leukaemia (PCL) patients. PCs were purified from bone marro...
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-2113 | biostudies-arrayexpress
TranscriptomicsTranscription profiling and genotyping of 26 human mantle cell lymphoma samples
Among B-cell lymphomas mantle cell lymphoma (MCL) has the worst prognosis. By using a combination of genomic and expression profiling (Affymetrix GeneChip Mapping 10k Xba131 and U133 set), we analysed 26 MCL samples to identify genes relevant to MCL pathogenesis and that could represent new therapeu...
ORGANISM(S): Homo sapiens 
2007-06-24 | E-GEOD-4176 | biostudies-arrayexpress
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