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TranscriptomicsERG induced mesenchymal like gene signature
ERG overexpression was conducted in stably transfected K562 cell line with a tet-on inducible plasmid habouring ERG3. Prolonged induction of ERG (8 days) produced spindle cell shape changes whereas non-induced cells retained the round morphology. In oder to determine the genes responsible for induci...
ORGANISM(S): Homo sapiens 
2013-10-19 | E-GEOD-51258 | biostudies-arrayexpress
Genomicsena-DATASET-MED-DUS-26-07-2016-11:14:36:814-193 - samples
26 cell lines derived from human Diffuse Large B Cell lymphomas (DLBCL) or Burkit Lymphomas (BL) were subjected to whole exome sequencing. Exome capture was carried out using the SeqCap EZ Exome Library 2.0 kit (Roche/Nimblegen) and 100 bp single-read sequencing was performed on a HiSeq2500 (Illumin...
EGAD00001002262 | EGA
GenomicsExome-sequencing of human B cell lymphoma cell lines
26 cell lines derived from human Diffuse Large B Cell lymphomas (DLBCL) or Burkit Lymphomas (BL) were subjected to whole exome sequencing. Exome capture was carried out using the SeqCap EZ Exome Library 2.0 kit (Roche/Nimblegen) and 100 bp single-read sequencing was performed on a HiSeq2500 (Illumin...
EGAS00001001463 | EGA
GenomicsSAHA-ZIM Data Access Committee
Data Access Committee EGAC00001000509
EGAC00001000509 | EGA
TranscriptomicsSilencing of GATA3 defines a novel stem cell like subgroup of ETP-ALL
Genome wide expression profiling was used to detect cases of adult T-ALL lacking GATA3 expression. GATA3low T-ALL exhibited enrichment of myeloid/lymphoid progenitor (MLP) and granulocyte/monocyte progenitor (GMP) genes, while T-cell specific signatures were downregulated. Among upregulated genes FL...
ORGANISM(S): Homo sapiens 
2016-02-26 | E-GEOD-78132 | biostudies-arrayexpress
TranscriptomicsGenome wide screen reveals WNT11, a noncanonical WNT gene, as a target of ETS transcription factor ERG
ERG is a transcription factor that is involved in leukomogenesis and its mRNA overexpression has been associated with poor prognosis in a subset of patients with T-cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML). Herein, a genome-wide screen of ERG target genes was conduct...
ORGANISM(S): Homo sapiens 
2010-12-10 | E-GEOD-21495 | biostudies-arrayexpress
TranscriptomicsMicroarray-based CGH using BAC clones
High resolution BAC array used to study changes in the copy number of chromosome 21 in Acute Meyloid Leukemia patients Genomic DNA from patients as well as from normal donors were differentially labelled and hybridized on the array 36 RPCI-11 BAC clones covering the q-arm of chromosome21 from positi...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1078 | biostudies-arrayexpress
TranscriptomicsTranscriptional Alterations in Bone Marrow Mesenchymal Stromal Cells derived from Acute Myeloid Leukemia patients (AML BM-MSC)
The aim of the study was to get insights into transcriptional alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients We compared the global gene expression profile from AML BM-MSC (n=19) to healthy donor (HD) controls (HD BM-MSC n=4) AML BM-MSC and HD BM-MS...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-84881 | biostudies-arrayexpress
TranscriptomicsMolecular alterations in bone marrow mesenchymal stromal cells (BM-MSC) derived from acute myeloid leukemia patients (AML)
Genome wide methylation profiling of BM-MSC derived from AML patients in comparison to healthy donor controls using Illumina Infinium HumanMethylation450 Beadchip bisulfit converted genomic DNA extracted from BM-MSC samples (AML n=32) and healthy donor controls (n=12) were hybridized onto an Illumi...
ORGANISM(S): Homo sapiens 
2016-03-30 | E-GEOD-79695 | biostudies-arrayexpress
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