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ProteomicsDetermining changes in the oxidized proteome of human CD8+ T cells with enhancing proteasome activity
Chronic T cell receptor (TCR) stimulation, combined with adverse conditions in the tumor microenvironment (TME) such as hypoxia and nutrient deprivation, frequently results in T cell exhaustion. Exhausted T cells (TEX) experience oxidative stress, which causes an accumulation of oxidized proteins wi...
ORGANISM(S): Homo sapiens (Human) 
2026-03-12 | PXD070152 | Pride
Exhausted t cells (tex) Oxidative stress Proteasome 
MetabolomicsSpecific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata
The native diploid tobacco Nicotiana attenuata produces abundant, potent anti-herbivore defense metabolites known as 17-hydroxygeranyllinalool diterpene glycosides (HGL-DTGs) whose glycosylation and malonylation biosynthetic steps are regulated by jasmonate signaling. To characterize the biosyntheti...
2021-10-06 | MTBLS1819 | MetaboLights
UnknownCephalometry in adults and children with neurofibromatosis type 1: Implications for the pathogenesis of sphenoid wing dysplasia and the "NF1 facies".
Not available
S-EPMC4659762 | biostudies-literature
ProteomicsThe small molecule lipoamide modulates stress granule condensation with beneficial outcomes for familial amyotrophic lateral sclerosis models
We have evaluate the in-situ targets of lipoamide - a compund that causes alteration of the fluidity of in-vito FUS condensate and dissolves stress granules in cells - in Hela cells stressed with 1 mM arsenate. We have used quantitative proteomics based thermal proteome profiling to characterise the...
ORGANISM(S): Homo sapiens (Human) 
2025-05-09 | PXD039501 | Pride
Target engagement Thermal proteome profiling Als Biomolecular condensates Lipoamide 
TranscriptomicsTemporal Gene Expression Patterns in the skin of D6 null and wild type mice after inflammation with the chemical irritant TPA
The chemokine decoy receptor D6 internalises and degrades inflammatory CC chemokines enabling resolution of inflammation. In D6 deficient mice (D6 KO), otherwise innocuous cutaneous inflammatory stimuli induce a grossly exaggerated inflammatory response that bears many similarities to human psoriasi...
ORGANISM(S): Mus musculus 
2013-05-28 | E-GEOD-46889 | biostudies-arrayexpress
ProteomicsAnalysis of reconstituted tripartite complex supports avidity-based recruitment of Hsp70 by substrate bound J-domain protein
Hsp70 are ubiquitous, versatile molecular chaperones that cyclically interact with substrate protein(s). The initial step requires synergistic interaction of a substrate and a J-domain protein (JDP) cochaperone, via its J-domain, with Hsp70 to stimulate hydrolysis of its bound ATP. This hydrolysis d...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2024-02-19 | PXD044739 | Pride
Hsc20 Hsp70 atpase cycle Substrate delivery Ssq1 Molecular chaperones 
UnknownSynergism, Bifunctionality, and the Evolution of a Gradual Sensory Trade-off in Hummingbird Taste Receptors.
Not available
S-EPMC8826506 | biostudies-literature
TranscriptomicsMicroarray Expression Analysis of SIV infection of Sooty Mangabeys
Natural SIV infection of sooty mangabeys (SMs) does not progress to disease despite chronic virus replication. In contrast to pathogenic SIV infection of rhesus macaques (RMs), chronic SIV infection of SMs is characterized by low immune activation. To elucidate the mechanisms underlying this phenoty...
ORGANISM(S): Cercocebus torquatus atys 
2010-03-08 | E-GEOD-16147 | biostudies-arrayexpress
ProteomicsLINE-1 ORF2p Structure. BS3 crosslinks
ORF2p was cross-linked using BS3 in order to gather experimental data that could help elucidate its structure.
ORGANISM(S): Homo sapiens (Human) 
2023-12-12 | PXD038615 | Pride
Orf2 orf2p line-1 bs3 structural proteomics 
TranscriptomicsGenomic Fingerprints of DC Subsets in the Human Vaginal Mucosa, Skin, and Blood
Dendritic cells (DC) localize throughout the body, where they sense and capture invading pathogens to induce protective immune responses. Hence, harnessing the biology of tissue-resident DC is crucial for the rational design of vaccines against pathogens. Herein, we characterized the transcriptomes ...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-54480 | biostudies-arrayexpress
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