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ProteomicsThe small molecule lipoamide modulates stress granule condensation with beneficial outcomes for familial amyotrophic lateral sclerosis models
Neurodegenerative diseases like amyotrophic lateral sclerosis are often associated with mutations in proteins which can form stress granules by liquid-liquid phase separation (LLPS). Formation of these condensate phases requires a complex molecular grammar for protein-protein interactions which, whe...
ORGANISM(S): Homo sapiens (Human) 
2025-05-09 | PXD039670 | Pride
Stress granule Small molecules Amyotrophic lateral sclerosis Molecular condensates Liquid-liquid phase separation 
UnknownLipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.
Not available
S-EPMC3894633 | biostudies-literature
ProteomicsThe small molecule lipoamide modulates stress granule condensation with beneficial outcomes for familial amyotrophic lateral sclerosis models
We have evaluate the in-situ targets of lipoamide - a compund that causes alteration of the fluidity of in-vito FUS condensate and dissolves stress granules in cells - in Hela cells stressed with 1 mM arsenate. We have used quantitative proteomics based thermal proteome profiling to characterise the...
ORGANISM(S): Homo sapiens (Human) 
2025-05-09 | PXD039501 | Pride
Target engagement Thermal proteome profiling Als Biomolecular condensates Lipoamide 
UnknownTriazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .
Not available
S-EPMC2827632 | biostudies-literature
UnknownMitochondrial Liver Toxicity of Valproic Acid and Its Acid Derivatives Is Related to Inhibition of α-Lipoamide Dehydrogenase.
Not available
S-EPMC5618561 | biostudies-literature
OtherSirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.
Data from ProteomeXchange, PXD ID: PXD001447. Experiment: SIRT4_MITO_MOCK1, file: SIRT4_MITO_MOCK1_05.mzml. Published as part of Cell. 2014 Dec 18;159(7):1615-25 . From the Abstract: {{i}} ... Here, we establish SIRT4 as a cellular lipoamidase that regulates the pyruvate dehydrogenase complex (PDH)...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320006423 | GPMDB
Resource Reanalysis 
UnknownWhole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions.
Not available
S-EPMC7888283 | biostudies-literature
UnknownNanogold Functionalized With Lipoamide-isoDGR: A Simple, Robust and Versatile Nanosystem for αvβ3-Integrin Targeting.
Not available
S-EPMC8194705 | biostudies-literature
UnknownShape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors.
Not available
S-EPMC10739260 | biostudies-literature
UnknownIndazole to 2-Cyanoindole Scaffold Progression for Mycobacterial Lipoamide Dehydrogenase Inhibitors Achieves Extended Target Residence Time and Improved Antibacterial Activity.
Not available
S-EPMC11887847 | biostudies-literature
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