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MetabolomicsNavigating natural variation in herbivory-induced secondary metabolism in coyote tobacco populations using MS/MS structural analysis
Natural variation can be extremely useful in unraveling the determinants of phenotypic trait evolution but has rarely been analyzed with unbiased metabolic profiling to understand how its effects are organized at the level of biochemical pathways. Native populations of Nicotiana attenuata, a wild to...
2015-06-15 | MTBLS203 | MetaboLights
MetabolomicsThe downside of metabolic diversity: Postingestive rearrangements by specialized insects
Deploying toxins in complex mixtures is thought to be advantageous and is observed during antagonistic interactions in nature. Toxin mixtures are widely utilized in medicine and pest control, as they are thought to slow the evolution of detoxification counterresponses in the targeted organisms. Here...
2022-12-04 | MTBLS3676 | MetaboLights
MetabolomicsIlluminating a plant’s tissue-specific metabolic diversity using computational metabolomics and information theory
While cross-tissue metabolite variations are increasingly regarded as important readouts of tissue-level gene regulatory processes, these have rarely been explored by non-targeted metabolomics. Here we explore tissue-level metabolic specialization in Nicotiana attenuata, an ecological model with ric...
2016-12-02 | MTBLS335 | MetaboLights
MetabolomicsSpecific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata
The native diploid tobacco Nicotiana attenuata produces abundant, potent anti-herbivore defense metabolites known as 17-hydroxygeranyllinalool diterpene glycosides (HGL-DTGs) whose glycosylation and malonylation biosynthetic steps are regulated by jasmonate signaling. To characterize the biosyntheti...
2021-10-06 | MTBLS1819 | MetaboLights
MetabolomicsDevelopment and validation of a liquid chromatography-electrospray ionization-time-of-flight mass spectrometry method for induced changes in Nicotiana attenuata leaves during simulated herbivory
Metabolite profiling of herbivory-induced changes in Nicotiana attenuata was used to construct a correlation-weighted network to visualize intra- and inter-compound spectra relationships from individual mass features, and to annotate 12 major network hubs, including 4 O-acyl sugars and 6 17-hydroxyg...
2012-08-14 | MTBLS10 | MetaboLights
TranscriptomicsTissue specific diurnal rhythm of transcripts and their regulation during herbivore attack in Nicotiana attenuata
Idenfication and characterization of oscillating transcripts after elicitation with oral secretions from the sepcialist herbivore, Manduca sexta larvae Source leaves, sink leaves and roots were collected every 4 h for one days.
ORGANISM(S): Nicotiana attenuata 
2011-12-29 | E-GEOD-30287 | biostudies-arrayexpress
TranscriptomicsNaMYC2 transcription factor regulates a subset of plant defense responses in Nicotiana attenuata
Identification of significantly altered transcripts in Nicotiana attenuata plants with reduced MYC2 expression after induction with oral secretions of Manduca sexta larvae. Gene expression in leaves of Nicotiana attenuata EV and MYC2_VIGS plants was measured at 1 hour after induction with oral secre...
ORGANISM(S): Nicotiana attenuata 
2013-05-17 | E-GEOD-45608 | biostudies-arrayexpress
GenomicsMelanoma Genome Sequencing Project

Melanoma is the most prevalent cause of skin cancer morbidity and mortality. In order to characterize the full range of somatic mutations that may drive the growth of melanoma, we are sequencing tumor and normal DNA from a set of roughly 150 melanomas. For the majority of samples (approximately 9...

phs000452.v1.p1 | EGA
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