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TranscriptomicsThe acute transcriptional response of the coral Acropora millepora to immune challenge: expression of GiMAP/IAN genes links the innate immune response of corals with those of mammals and plants
This studies investigates the acute response of the coral Acropora millepora to two immunogenes: MDP (bacterial mimic) and pIC (viral mimic). Three members of the GiMAP familly were found to respond strongly to MDP treatment, showing analalogy to the immune response in vertebrates and plants. Differ...
ORGANISM(S): Acropora millepora 
2013-11-05 | E-GEOD-46389 | biostudies-arrayexpress
TranscriptomicsSystems Biology Analysis of Tenofovir 1% Gel in a Phase I Rectal Microbicide Trial
In MTN-007, a phase 1, randomized, double-blinded rectal microbicide trial, we used systems genomics/proteomics to determine the effect of tenofovir 1% gel, nonoxynol-9 2% gel, placebo gel or no treatment on rectal biopsies taken at baseline, after one application or after seven daily applications (...
ORGANISM(S): Homo sapiens 
2015-02-23 | E-GEOD-57025 | biostudies-arrayexpress
UnknownThe acute transcriptional response of the coral Acropora millepora to immune challenge: expression of GiMAP/IAN genes links the innate immune responses of corals with those of mammals and plants.
Not available
S-EPMC3723955 | biostudies-literature
TranscriptomicsEx vivo effects of Tenofovir on four vaginal epithelial cell lines
In MTN-007, a phase 1, randomized, double-blinded rectal microbicide trial, we used systems genomics/proteomics to determine the effect of tenofovir 1% gel, nonoxynol-9 2% gel, placebo gel or no treatment on rectal biopsies taken at baseline, after one application or after seven daily applications (...
ORGANISM(S): Homo sapiens 
2015-02-23 | E-GEOD-57026 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of human fetal duodenal enteroids grown in EGF and/or NRG1
The purpose of this study was to interrogate the role of EGF-family ligands, in particular Epidermal Growth Factor (EGF) and Neuregulin 1 (NRG1), as human intestinal stem cell niche factors. An established duodenal enteroid line derived from a 20.2 week post conception biological specimen was expose...
ORGANISM(S): Homo sapiens 
2020-12-10 | E-MTAB-9720 | biostudies-arrayexpress
GenomicsELK1 ChIP-seq
Chromatin immunoprecipitation of ELK1 in MCF10A cells detected by SOLiD sequencing
ORGANISM(S): Homo sapiens 
2012-08-20 | E-MTAB-830 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of paired non small cell lung carcinoma tissue and peripheral blood from 5 donors
The immunosuppressive tumour microenvironment constitutes a significant hurdle to immune checkpoint inhibitors response. Both soluble factors and specialised immune cells such as regulatory T cells (TReg) are key components of active intratumoural immunosuppression. Previous studies have shown that ...
ORGANISM(S): Homo sapiens 
2020-09-01 | E-MTAB-9451 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of human fetal intestine tissue
Here, we performed single cell RNA sequencing (scRNA-seq) of human fetal duodenal tissue samples from 8 individual biological specimens across 7-21 weeks of gestation. The data set is composed of over 37,000 cells (between 3,000-9,000 cells per time point) from diverse intestinal lineages. Lineages ...
ORGANISM(S): Homo sapiens 
2020-12-12 | E-MTAB-9489 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of pluripotent stem cell derived human intestinal organoids
Here, we used single cell RNA-sequencing (scRNA-seq) to profile pluripotent stem cell derived human intestinal organoids (HIOs) grown in matrigel or a non-adhesive alginate hydrogel after 28 days of in vitro growth. Additionally, we used scRNA-seq to profile HIOs derived in the presence of Neureguli...
ORGANISM(S): Homo sapiens 
2021-05-21 | E-MTAB-10268 | biostudies-arrayexpress
TranscriptomicsMicroRNAs expression profiling during breast cancer progression
MicroRNAs (miRNAs) are known to be deregulated in human breast cancer (BC). The purpose of the current study was to investigate the expression of miRNAs in different stages of BC to assess their biological value in BC progression. MiRNA expression was assessed in a series of BC patients (n=7) with d...
ORGANISM(S): Homo sapiens 
2012-06-22 | E-GEOD-38867 | biostudies-arrayexpress
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