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TranscriptomicsTranscription profiling of human fetal lung epithelial cells in undifferentiated state and after type II cell differentiation induced by DCI treatment
Studies of human fetal lung in explant culture and in isolated epithelial cells have demonstrated that both glucocorticoids and cyclic AMP promote differentiated alveolar type II cell phenotype as assessed by ultrastructural morphology and surfactant production. This project profiles changes in gen...
ORGANISM(S): Homo sapiens 
2007-11-22 | E-GEOD-3306 | biostudies-arrayexpress
TranscriptomicsGene Expression in Human Lung Type II Cells
Normal lung function relies on mature function of alveolar type II cels, which have numerous functions including to regulate ion and fluid flux, produce immune molecules, and synthesize and secrete surfactant to stabilize air spaces. Differentiation of type II cells from precursor epithelial cells ...
ORGANISM(S): Homo sapiens 
2009-12-30 | E-GEOD-19699 | biostudies-arrayexpress
TranscriptomicsAnti-Inflammatory Effects of Budesonide in Human Fetal Lung
Rationale. Lung inflammation in premature infants contributes to development of bronchopulmonary dysplasia (BPD), a chronic lung disease with long-term sequelae. Pilot studies administering budesonide suspended in surfactant have found reduced BPD without apparent adverse effects as occur with syste...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-83888 | biostudies-arrayexpress
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