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ModelsHesse2021 - Interplay between core-clock and cancer drug irinotecan pharmacokinetics and -dynamics
Refined quantitative core-clock model based on the model by Relógio et al. 2011. The translation-transcription network is extended by a set of irinotecan-relevant genes, which allows to connect the core clock to the irinotecan pharmacokinetics and -dynamics model by Ballesta et al. 2011. The origina...
2021-09-15 | MODEL2109140001 | BioModels
ModelsStephanou2019 - pH as a potential therapeutic target to improve temozolomide antitumor efficacy
Abstract: Despite intensive treatments including temozolomide (TMZ) administration, glioblastoma patient prognosis remains dismal and innovative therapeutic strategies are urgently needed. A systems pharmacology approach was undertaken to investigate TMZ pharmacokinetics‐pharmacodynamics (PK‐PD) inc...
2019-09-30 | MODEL1909300003 | BioModels
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