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ProteomicsMS imaging-guided microproteomics for spatial omics on a single instrument
Mass spectrometry imaging (MSI) allows investigating the spatial distribution of chemical compounds directly in biological tissues. As the analytical depth of MSI is limited, MSI needs to be coupled to more sensitive local extraction-based omics approaches to achieve a comprehensive molecular charac...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD020362 | Pride
Spatial omics Microproteomics Laser microdissection Mass spectrometry imaging 
ProteomicsMachine learning for grading and prognosis of esophageal dysplasia using mass spectrometry and histological imaging
Background: Barrett’s esophagus (BE) is a precursor lesion of esophageal adenocarcinoma and may progress from non-dysplastic through low-grade dysplasia (LGD) to high-grade dysplasia (HGD) and cancer. Grading BE is of crucial prognostic value and is currently based on the subjective evaluation of bi...
ORGANISM(S): Homo sapiens (Human) 
2021-11-15 | PXD028949 | Pride
Deep learning Mass spectrometry imaging H&e staining Barrett’s esophagus Machine learning 
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