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TranscriptomicsCulture condition comparisons of WTC11 hiPSC by single-cell RNAseq and featuring differences between cE8, hE8 and B8+ media
This single-cell RNA-sequencing experiment was performed for the study “Refined and benchmarked homemade media for cost-effective, weekend-free human pluripotent stem cell culture.” Human induced pluripotent stem cells (hiPSCs) from the WTC-11 line were adapted to three defined media: cE8, hE8, and ...
ORGANISM(S): Homo sapiens 
2025-09-19 | E-MTAB-15570 | biostudies-arrayexpress
TranscriptomicsiPS2-multi-seq on early pasage (P3) iPS2-seq targeted hiPSC
We aimed to identify the nature of iPSC and iPSC-neuro clones identified in E-MTAB-14065. We evaluated the combined effect on the epigenome and transcription at the single-cell level. This experiment demonstrated the importance of clonal tracking when performing scRNAseq screenings and allowed us to...
ORGANISM(S): Homo sapiens 
2025-10-27 | E-MTAB-15332 | biostudies-arrayexpress
TranscriptomicsiPS2-10X-seq Neural organoid differentiation
iPS2-10X-seq on Neural organoid differentiation after 35days of differentiation. This experiment is a proof of principle that iPS2seq can be applied to different differentiation strategies without risk of silencing. This experiment also showed how neuro-iPSC clones differentiate preferentially towar...
ORGANISM(S): Homo sapiens 
2025-10-27 | E-MTAB-15308 | biostudies-arrayexpress
TranscriptomicsBulk RNA sequencing of cardiac organoids differentiated from hiPSC-derived cell lines with knockdown of factors involved in early cardiac specification
This dataset was generated to investigate the role of two DNA-binding factors, CTCF and GATA4, in early cardiac specification. Three WTC11-derived hiPSC lines were employed, each carrying a stably integrated shRNA construct. Two of the constructs specifically target CTCF and GATA4, while the third e...
ORGANISM(S): Homo sapiens 
2025-10-14 | E-MTAB-15710 | biostudies-arrayexpress
TranscriptomicsBulk RNA sequencing of cardiomyocytes differentiated in monolayer (2D) from hiPSC-derived cell lines with tetracycline-inducible knockdown of CTCF and GATA4
This dataset was generated to study the role of the DNA-binding factors CTCF and GATA4 in cardiac specification. Three WTC11-derived hiPSC lines were used, each carrying a stably integrated shRNA construct. Two constructs specifically target CTCF and GATA4, while the third expresses a scrambled, non...
ORGANISM(S): Homo sapiens 
2025-10-14 | E-MTAB-15684 | biostudies-arrayexpress
TranscriptomicsRNA-seq of hiPSCs adapted to homemade weekend-free media
Homemade weekend free media are a promising way for the labs to reduce the manpower and high costs associated with the culture of human induced pluripotent stem cells (hiPSCs) in feeder-free conditions. However, as these media would have a different concentration of various growth factors, cells may...
ORGANISM(S): Homo sapiens 
2024-07-11 | E-MTAB-14237 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Group 2 innate lymphoid cells (ILC2) from uterine tissue (Virgin, E9.5, E18.5)
Group 2 innate lymphoid cells (ILC2) promote the production of a type-2 immunological environment in the uterus and have tissue-specific gene signatures that change with pregnancy.
ORGANISM(S): Mus musculus 
2023-04-15 | E-MTAB-5803 | biostudies-arrayexpress
UnknownSingle Cell Transcriptional Perturbome in Pluripotent Stem Cell Models
Not available
S-SCDT-10_1038-S44320-025-00172-8 | biostudies-other
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