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Proteomics,MultiomicsElectrophilic stress induced by itaconate and its derivatives regulates ATF3-IKBZ inflammatory axis independently of Nrf2 induction
Metabolic regulation recently emerged as a novel powerful principle guiding immune responses. The natural metabolite itaconate and its membrane permeable derivative dimethyl itaconate (DI) were recently shown to selectively inhibit a subset of cytokines during macrophage activation, yet the precise ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2018-02-25 | MSV000082101 | MassIVE
TranscriptomicsItaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation
Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation mechanism accompanying inflammatory macrophage activation. During this process, endogenous metabolites can adopt regulatory roles that govern specific aspects of inflammatory response, as recently shown for succinate, which r...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-82043 | biostudies-arrayexpress
ProteomicsItaconate modulates immune responses via inhibition of peroxiredoxin 5
Wild type and Irg1 knockout mouse bone marrow derived macrophages (BMDMs) were processed with a redox proteomics workflow and analyzed by LC-MS/MS with TMT based quantification.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-11-01 | MSV000093232 | MassIVE
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