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ProteomicsResource misallocation as a mediator of fitness costs in antibiotic resistance
Antimicrobial resistance (AMR) poses a threat to global health and the economy. Rifampicin resistant Mycobacterium tuberculosis accounts for a third of the global AMR burden. Gaining the upper hand on AMR requires a deeper understanding of the physiology of resistance. AMR often results in the eros...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2021-03-12 | PXD011568 | Pride
Genomics Clinical isolates Mycobacterium tuberculosis Systems biology Transcriptomics Drug resistance Proteomics 
ProteomicsNetwork analysis identifies regulators of lineage-specific phenotypes in Mycobacterium tuberculosis
The Mycobacterium tuberculosis (Mtb) complex comprises seven phylogenetically distinct human-adapted lineages exhibiting different geographical distribution and degrees of pathogenicity. Among these, Lineage 1 (L1) has been associated with low virulence whereas Lineage 2 (L2) has been linked to hype...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2026-01-27 | PXD017194 | Pride
Bacterial pathogen Proteomics Multi-omics Mycobacterium tuberculosis Infectious diseases Genomics Dia/swath-ms Transcriptional network 
ProteomicsNCI60 proteome by PCT-SWATH - Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines
We obtained quantitative analysis of the NCI-60 cell panels using pressure cycling technology (PCT) and SWATH-MS. Each cell was analyzed in duplicate. The data were analyzed using a cell line SWATH assay library and OpenSWATH, followed by SWATH-expert refinement.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-29 | MSV000085848 | MassIVE
ProteomicsFrom coarse to fine: The absolute Escherichia coli proteome under diverse growth conditions
Accurate measurements of cellular protein concentrations are invaluable to quantitative studies of gene expression and physiology in living cells. Here, we developed a versatile mass spectrometric workflow based on data-independent acquisition proteomics (DIA/SWATH) together with a novel protein inf...
ORGANISM(S): Escherichia Coli 
2022-01-12 | PXD017258 | panorama
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