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GenomicsRepressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (Illumina)
In higher eukaryotes, histone methylation is involved in the maintenance of cellular identity during somatic development. During spermatogenesis, Since most nucleosomes are replaced by protamines during spermatogenesis . Iit is therefore unclear whether if histone modifications function in paternal ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-19889 | biostudies-arrayexpress
TranscriptomicsRepressive and active histone methylation mark distinct promoters in human and mouse spermatozoa
This SuperSeries is composed of the following subset Series: GSE13863: Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (Nimblegen) GSE19889: Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (Illumina) Re...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-19892 | biostudies-arrayexpress
GenomicsTargeting H3K4 methylation as a therapeutic strategy for Huntington's disease (ChIP-seq)
Transcriptional dysregulation is an early feature of Huntington's disease (HD). We observed gene-specific changes in H3K4me3 at transcriptionally repressed promoters in R6/2 mouse and human HD brain. Genome-wide analysis showed a novel chromatin signature for this mark. Reducing the levels of the H3...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-48960 | biostudies-arrayexpress
TranscriptomicsPolycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions of Jarid2 in transcriptional regulation in Drosophila
This SuperSeries is composed of the following subset Series: GSE33546: Polycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions of Jarid2 in transcriptional regulation in Drosophila [ChIP-Seq] GSE36038: Polycomb repressive complex 2-dependent and M-bM-^@M-^Sindependent functions ...
ORGANISM(S): Drosophila melanogaster 
2012-02-23 | E-GEOD-36039 | biostudies-arrayexpress
ProteomicsPhosphorylation sites that influences the RNA-binding activity of Papi
We conducted UV cross-linking immunoprecipitation (CLIP) with and without phosphatase inhibitor and compared the outcome. The topmost band on the western blots appeared more prominent with the inhibitor. The RNA-binding activity of the band was also stronger with the inhibitor. We isolated the band ...
ORGANISM(S): Bombyx Mori 
2022-02-01 | PXD027395 | JPOST Repository
GenomicsEffect of LINC00899 depletion on histone mark enrichment in HeLa cells
LncRNAs represent a major transcriptional output of the human genome, but the function of many of these elements is unknown. In this experiment, we have used the ‘CUT&RUN’ technique to quantify the changes in histone mark enrichment across the genome upon depletion of the lncRNA LINC00899 in HeLa ce...
ORGANISM(S): Homo sapiens 
2019-03-29 | E-MTAB-7419 | biostudies-arrayexpress
GenomicsAcetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency
The presence of acetylated histone H3K56 in human embryonic stem cells (ESCs) correlates positively with the binding of Nanog, Sox2 and Oct4 (NSO) transcription factors at their target gene promoters. However, the function of H3K56ac there has been unclear. We now report that Oct4 interacts with K56...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-47387 | biostudies-arrayexpress
TranscriptomicsGenomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells (RNA-seq)
Cellular differentiation entails reprogramming of the transcriptome from a pluripotent to a unipotent fate. This process was suggested to coincide with a global increase of repressive heterochromatin, which results in a reduction of transcriptional plasticity and potential. Here we report the dynami...
ORGANISM(S): Mus musculus 
2011-06-21 | E-GEOD-27843 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling by microarray of Caenorhabditis elegans MT2124 x CB4856 RILs used for eQTL mapping
We crossed the MT2124 strain carrying the let-60 (n1046) gain of function mutation with the wild-type strain CB4856. From this cross a panel of mutation introgression recombinant inbred lines (miRILs) was generated. Using this population, the influence of genetic variation on the the let-60 (gf) mut...
ORGANISM(S): Caenorhabditis elegans 
2017-07-21 | E-MTAB-5856 | biostudies-arrayexpress
GenomicsPOLIISER5 and POLIISER2 ChIP-Seq in mutant RNAi LID Drosophila Melanogaster
LID is a histone demethylase acting on H3K4me3, a mark related to transcription and found near the transcription start sites (TSS) of the genes. We analyzed where POLIISER5 and POLIISER2 are localized in LID RNAi mutants. 1 sample for POLIISER5 with an input control, and 1 sample for POLIISER2 with ...
ORGANISM(S): Drosophila melanogaster 
2012-09-04 | E-GEOD-40599 | biostudies-arrayexpress
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