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The ability to simultaneously sequence the genome and transcriptome of the same single cell offers a powerful means to dissect functional genetic heterogeneity at the cellular level. Here we describe G&T-seq, a method for separating and sequencing genomic DNA and full-length mRNA from single cells. ...
CD3-positive T cells were negatively isolated from 10 SLE patients and 9 healthy controls without SLE. All of the SLE samples and control samples were compared with one another to identify baseline differences in expression due to the disease. Next, T cell preparations from 4 of the control subjec...
ORGANISM(S): Homo sapiens 
RNA was harvested from T-bet deficient MEP cells versus "wild type" C57BL/6 control MEP cells freshly harvested from bone marrow. 3 samples in each group, representing MEP cells from three different T-bet deficient or control mice.
ORGANISM(S): Mus musculus 
In psoriasis, inflammation and epidermal hyperplasia are thought to be controlled by T cell-derived cytokines. Evidence now suggests that Th17 and Th22 cells infiltrate psoriasis lesions and by secreting IL-17 and IL-22, respectively, may drive disease-specific gene or cell responses. While studies ...
ORGANISM(S): Homo sapiens 
MODELING THE INTERACTION BETWEEN AVASCULAR CANCEROUS CELLS AND ACQUIRED IMMUNE RESPONSE B. DUBEY, UMA S. DUBEY and SANDIP BANERJEE Abstract This paper deals with the interaction between dispersed cancer cells and the major populations of the immune system, namely, the T helper cells, T Cytotoxic ...
2024-09-02 | BIOMD0000000886 | BioModels
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